Scholarly Works - MRC Biostatistics Unit
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Recent Submissions
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Second-order estimating equations for clustered current status data from family studies using response-dependent sampling
(Springer Nature, 2017-07-24)Studies about the genetic basis for disease are routinely conducted through family studies under response-dependent sampling in which affected individuals called probands are sampled from a disease registry, and their ... -
The Hartung-Knapp modification for random-effects meta-analysis: A useful refinement but are there any residual concerns?
(Wiley-Blackwell, 2017-07-26)The modified method for random-effects meta-analysis, usually attributed to Hartung andKnapp and also proposed by Sidik and Jonkman, is easy to implement and is becoming advocated for general use. Here, we examine a range ... -
Statistical issues in first-in-human studies on BIA 10-2474: Neglected comparison of protocol against practice
(Wiley, 2017-03)By setting the regulatory-approved protocol for a suite of first-in-human studies on BIA 10-2474 against the subsequent French investigations, we highlight six key design and statistical issues which reinforce recommendations ... -
Power analysis to detect treatment effects in longitudinal clinical trials for Alzheimer's disease
(elsevier, 2017-09-01)Introduction Assessing cognitive and functional changes at the early stage of Alzheimer's disease (AD) and detecting treatment effects in clinical trials for early AD are challenging. Methods Under the assumption that ...
