Scholarly Works - MRC Biostatistics Unit

An optimised multi-arm multi-stage clinical trial design for unknown variance.

Grayling, Michael; Wason, James; Mander, Adrian (Elsevier BV, 2018-04)

Multi-arm multi-stage trial designs can bring notable gains in efficiency to the drug development process. However, for normally distributed endpoints, the determination of a design typically depends on the assumption that ...
Increased uptake and new therapies are needed to avert rising hepatitis C-related end stage liver disease in England: modelling the predicted impact of treatment under different scenarios.

Harris, Ross J; Thomas, Brenda; Griffiths, Jade; Costella, Annastella; Chapman, Ruth; Ramsay, Mary; De Angelis, DanielaHarris, Helen E et al. (2014-09)
Calibration of complex models through Bayesian evidence synthesis: a demonstration and tutorial.

Jackson, Christopher; Jit, Mark; Sharples, Linda D; De Angelis, Daniela (2015-02)
Estimating HIV Incidence, Time to Diagnosis, and the Undiagnosed HIV Epidemic Using Routine Surveillance Data.

van Sighem, Ard; Nakagawa, Fumiyo; De Angelis, Daniela; Quinten, Chantal; Bezemer, Daniela; de Coul, Eline Op; Egger, Matthiasde Wolf, FrankFraser, ChristophePhillips, Andrew et al. (2015-09)