Theses - MRC Biostatistics Unit
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Recent Submissions
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Adaptive Designs and Methods for More Efficient Drug Development
The development of a novel drug is a time-consuming and expensive process. Innovative trial designs and optimal sequences of clinical trials aim to increase the efficiency of this process by improving flexibility and ... -
Modularized Bayesian Inference: Methodology, Algorithm, Theory And Application.
Bayesian inference has shown powerful impacts on understanding and explaining data and their generating mechanisms, but misspecification of the model is a major threat to the validity of the inference. Although methods ... -
Statistical methods to improve understanding of the genetic basis of complex diseases
Robust statistical methods, utilising the vast amounts of genetic data that is now available, are required to resolve the genetic aetiology of complex human diseases including immune-mediated diseases. Essential to this ... -
Approaches to developing clinically useful Bayesian risk prediction models
Prediction of the presence of disease (diagnosis) or an event in the future course of disease (prognosis) becomes increasingly important in the current era of personalised medicine. Both tasks (diagnosis and prognosis) are ...
