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dc.contributor.authorHiggins, MKen
dc.contributor.authorLane-Serff, Hen
dc.contributor.authorMacGregor, Paulaen
dc.contributor.authorCarrington, Marken
dc.date.accessioned2017-02-09T16:00:01Z
dc.date.available2017-02-09T16:00:01Z
dc.date.issued2017-01-26en
dc.identifier.issn1553-7366
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/262424
dc.description.abstractAfrican trypanosomes have complex life cycles comprising at least ten developmental forms, variously adapted to different niches in their tsetse fly vector and their mammalian hosts. Unlike many other protozoan pathogens, they are always extracellular and have evolved intricate surface coats that allow them to obtain nutrients while also protecting them from the immune defenses of either insects or mammals. The acquisition of macromolecular nutrients requires receptors that function within the context of these surface coats. The best understood of these is the haptoglobin-hemoglobin receptor (HpHbR) of $\textit{Trypanosoma brucei}$, which is used by the mammalian bloodstream form of the parasite, allowing heme acquisition. However, in some primates it also provides an uptake route for trypanolytic factor-1, a mediator of innate immunity against trypanosome infection. Recent studies have shown that during the evolution of African trypanosome species the receptor has diversified in function from a hemoglobin receptor predominantly expressed in the tsetse fly to a haptoglobin-hemoglobin receptor predominantly expressed in the mammalian bloodstream. Structural and functional studies of homologous receptors from different trypanosome species have allowed us to propose an evolutionary history for how one receptor has adapted to different roles in different trypanosome species. They also highlight the challenges that a receptor faces in operating on the complex trypanosome surface and show how these challenges can be met.
dc.description.sponsorshipThis has been funded by the Medical Research Council (Grant reference MR/L008246/1) and the Wellcome Trust (reference: 101020/Z/13/Z).
dc.languageengen
dc.language.isoenen
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleA Receptor's Tale: An Eon in the Life of a Trypanosome Receptoren
dc.typeArticle
prism.issueIdentifier1en
prism.numbere1006055en
prism.publicationDate2017en
prism.publicationNamePLoS Pathogensen
prism.volume13en
dc.identifier.doi10.17863/CAM.7688
dcterms.dateAccepted2016-11-14en
rioxxterms.versionofrecord10.1371/journal.ppat.1006055en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-01-26en
dc.contributor.orcidMacGregor, Paula [0000-0003-0919-3745]
dc.contributor.orcidCarrington, Mark [0000-0002-6435-7266]
dc.identifier.eissn1553-7374
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/L008246/1)
cam.issuedOnline2017-01-26en


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International