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dc.contributor.authorGarcia Rodriguez, Raulen
dc.contributor.authorHanf, Schirinen
dc.contributor.authorBond, Andrewen
dc.contributor.authorWright, Dominicen
dc.date.accessioned2017-03-06T11:14:23Z
dc.date.available2017-03-06T11:14:23Z
dc.date.issued2017-01-21en
dc.identifier.issn1359-7345
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/262879
dc.description.abstractHere we illustrate a new method for the rapid determination of ee’s of chiral alcohols using the thermally-stable, non-chiral lithium aluminate reagent [EtAl(6-Me-2-py)$_3$Li] (1). $\textit{In situ}$ reaction of the alcohols with 1 produces robust dimers in solution, present as diastereomeric pairs ($\textit{SS/RR}$ and $\textit{RS}$) with distinct resonances in their $^1$H and $^7$Li NMR spectra. The ee can be calculated simply from integration of the $^1$H and/or $^7$Li NMR spectra.
dc.description.sponsorshipWe thank the EU for a Marie Curie Intra European Fellowship within the seventh European Community Framework Programme (R. G. R.) and an Advanced Investigator Award (D. S. W.). We also thank the Fonds der Chemischen Industrie and the Studienstiftung des deutschen Volkes (Scholarships for S. H.).
dc.languageengen
dc.language.isoenen
dc.publisherRoyal Society of Chemistry
dc.titleA non-chiral lithium aluminate reagent for the determination of enantiomeric excess of chiral alcoholsen
dc.typeArticle
prism.endingPage1228
prism.issueIdentifier7en
prism.publicationDate2017en
prism.publicationNameChemical Communicationsen
prism.startingPage1225
prism.volume53en
dc.identifier.doi10.17863/CAM.8170
dcterms.dateAccepted2016-12-07en
rioxxterms.versionofrecord10.1039/c6cc09671aen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-01-21en
dc.contributor.orcidGarcia Rodriguez, Raul [0000-0003-0699-3894]
dc.contributor.orcidHanf, Schirin [0000-0003-2624-7872]
dc.contributor.orcidBond, Andrew [0000-0002-1744-0489]
dc.contributor.orcidWright, Dominic [0000-0002-9952-3877]
dc.identifier.eissn1364-548X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEPSRC (EP/K039520/1)
cam.issuedOnline2016-12-07en
rioxxterms.freetoread.startdate2017-12-07


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