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dc.contributor.authorCrawford, JEen
dc.contributor.authorAlves, JMen
dc.contributor.authorPalmer, WJen
dc.contributor.authorDay, Jonathanen
dc.contributor.authorSylla, Men
dc.contributor.authorRamasamy, Ren
dc.contributor.authorSurendran, SNen
dc.contributor.authorBlack, WCen
dc.contributor.authorPain, Aen
dc.contributor.authorJiggins, Francisen
dc.date.accessioned2017-04-03T15:14:08Z
dc.date.available2017-04-03T15:14:08Z
dc.date.issued2017-02-28en
dc.identifier.issn1741-7007
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/263450
dc.description.abstract$\textbf{BACKGROUND}$: The mosquito $\textit{Aedes aegypti}$ is the main vector of dengue, Zika, chikungunya and yellow fever viruses. This major disease vector is thought to have arisen when the African subspecies $\textit{Ae. aegypti}$ formosus evolved from being zoophilic and living in forest habitats into a form that specialises on humans and resides near human population centres. The resulting domestic subspecies, $\textit{Ae. aegypti aegypti}$, is found throughout the tropics and largely blood-feeds on humans. $\textbf{RESULTS}$: To understand this transition, we have sequenced the exomes of mosquitoes collected from five populations from around the world. We found that $\textit{Ae. aegypti}$ specimens from an urban population in Senegal in West Africa were more closely related to populations in Mexico and Sri Lanka than they were to a nearby forest population. We estimate that the populations in Senegal and Mexico split just a few hundred years ago, and we found no evidence of $\textit{Ae. aegypti aegypti}$ mosquitoes migrating back to Africa from elsewhere in the tropics. The out-of-Africa migration was accompanied by a dramatic reduction in effective population size, resulting in a loss of genetic diversity and rare genetic variants. $\textbf{CONCLUSIONS}$: We conclude that a domestic population of $\textit{Ae. aegypti}$ in Senegal and domestic populations on other continents are more closely related to each other than to other African populations. This suggests that an ancestral population of $\textit{Ae. aegypti }$evolved to become a human specialist in Africa, giving rise to the subspecies $\textit{Ae. aegypti aegypti}$. The descendants of this population are still found in West Africa today, and the rest of the world was colonised when mosquitoes from this population migrated out of Africa. This is the first report of an African population of Ae. aegypti aegypti mosquitoes that is closely related to Asian and American populations. As the two subspecies differ in their ability to vector disease, their existence side by side in West Africa may have important implications for disease transmission.
dc.description.sponsorshipThis work was funded by European Research Council grant Drosophila Infection 281668 to FMJ, a KAUST AEA award to FMJ and AP, a Medical Research Council Centenary Award to WJP and a National Institutes of Health Ruth L. Kirschstein National Research Service Award to JC.
dc.languageengen
dc.language.isoenen
dc.publisherBioMed Central
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectAedes aegyptien
dc.subjectanthropophilicen
dc.subjectarboviral diseasesen
dc.subjectdengue virusen
dc.subjectmosquito evolutionen
dc.subjectvector-borne diseasesen
dc.subjectZika virusen
dc.titlePopulation genomics reveals that an anthropophilic population of $\textit{Aedes aegypti}$ mosquitoes in West Africa recently gave rise to American and Asian populations of this major disease vectoren
dc.typeArticle
prism.number16en
prism.publicationDate2017en
prism.publicationNameBMC Biologyen
prism.volume15en
dc.identifier.doi10.17863/CAM.8796
dcterms.dateAccepted2017-01-19en
rioxxterms.versionofrecord10.1186/s12915-017-0351-0en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-02-28en
dc.contributor.orcidDay, Jonathan [0000-0002-4386-3020]
dc.contributor.orcidJiggins, Francis [0000-0001-7470-8157]
dc.identifier.eissn1741-7007
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEuropean Research Council (281668)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International