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dc.contributor.authorZhou, Yinen
dc.contributor.authorAbel, GAen
dc.contributor.authorHamilton, Wen
dc.contributor.authorPritchard-Jones, Ken
dc.contributor.authorGross, CPen
dc.contributor.authorWalter, Fionaen
dc.contributor.authorRenzi, Cen
dc.contributor.authorJohnson, Sen
dc.contributor.authorMcPhail, Sen
dc.contributor.authorElliss-Brookes, Len
dc.contributor.authorLyratzopoulos, Georgiosen
dc.date.accessioned2017-05-02T10:41:59Z
dc.date.available2017-05-02T10:41:59Z
dc.date.issued2017-01-01en
dc.identifier.issn1759-4774
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/263936
dc.description.abstractMany patients with cancer are diagnosed through an emergency presentation, which is associated with inferior clinical and patient-reported outcomes compared with those of patients who are diagnosed electively or through screening. Reducing the proportion of patients with cancer who are diagnosed as emergencies is, therefore, desirable; however, the optimal means of achieving this aim are uncertain owing to the involvement of different tumour, patient and health-care factors, often in combination. Most relevant evidence relates to patients with colorectal or lung cancer in a few economically developed countries, and defines emergency presentations contextually (that is, whether patients presented to emergency health-care services and/or received emergency treatment shortly before their diagnosis) as opposed to clinically (whether patients presented with life-threatening manifestations of their cancer). Consistent inequalities in the risk of emergency presentations by patient characteristics and cancer type have been described, but limited evidence is available on whether, and how, such presentations can be prevented. Evidence on patients' symptoms and health-care use before presentation as an emergency is sparse. In this Review, we describe the extent, causes and implications of a diagnosis of cancer following an emergency presentation, and provide recommendations for public health and health-care interventions, and research efforts aimed at addressing this under-researched aspect of cancer diagnosis.
dc.languageengen
dc.language.isoenen
dc.publisherNature Publishing Group
dc.titleDiagnosis of cancer as an emergency: a critical review of current evidenceen
dc.typeArticle
prism.endingPage56
prism.issueIdentifier1en
prism.publicationDate2017en
prism.publicationNameNature Reviews Clinical Oncologyen
prism.startingPage45
prism.volume14en
dc.identifier.doi10.17863/CAM.9312
dcterms.dateAccepted2016-09-09en
rioxxterms.versionofrecord10.1038/nrclinonc.2016.155en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-01-01en
dc.contributor.orcidWalter, Fiona [0000-0002-7191-6476]
dc.contributor.orcidLyratzopoulos, Georgios [0000-0002-2873-7421]
dc.identifier.eissn1759-4782
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idNational Institute for Health Research (NIHR) (via University of Bristol) (RP PG 0608 10045)
cam.issuedOnline2016-10-19en
rioxxterms.freetoread.startdate2017-04-19


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