MRC Mitochondrial Biology Unit
About this community
Collections in this community
Recent Submissions
-
Developing drugs to attenuate succinate accumulation and oxidation
(2019-04-27)Ischaemia-reperfusion (IR) injury is caused by the re-introduction of oxygen to organs, following periods of reduced blood flow (ischaemia). Whilst re-establishing blood flow (reperfusion) to the heart following myocardial ... -
Studies on assembly and genetic variation in mitochondrial respiratory complex I
(2019-03-30)Complex I (NADH:ubiquinone oxidoreductase) couples electron transfer to proton translocation across the inner mitochondrial membrane, to drive the synthesis of ATP. Its distinctive L-shaped structure comprises 45 subunits, ... -
Comparative phylogenetic exploration of the human mitochondrial proteome: Insights into disease and metabolism
(2019-02-23)Mitochondria are a key organelle within human cells, with functions ranging from ATP synthesis to apoptosis. Changes in mitochondrial function are associated with many diseases, as well as ‘natural’ processes like ageing. ... -
Developing mouse complex I as a model system: structure, function and implications in mitochondrial diseases.
(2018-10-20)Complex I (NADH:ubiquinone oxidoreductase), located in the mitochondrial inner membrane, is a major electron entry point to the respiratory chain. It couples the energy released from electron transfer (from NADH to ubiquinone) ...
