MRC Mitochondrial Biology Unit
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Respiratory Complex I in Bos taurus and Paracoccus denitrificans Pumps Four Protons across the Membrane for Every NADH Oxidized.
(2017-03)Respiratory complex I couples electron transfer between NADH and ubiquinone to proton translocation across an energy-transducing membrane to support the proton-motive force that drives ATP synthesis. The proton-pumping ... -
Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states.
(Springer Nature, 2018-07)Complex I (NADH:ubiquinone oxidoreductase) uses the reducing potential of NADH to drive protons across the energy-transducing inner membrane and power oxidative phosphorylation in mammalian mitochondria. Recently, cryoEM ... -
Transporter gene acquisition and innovation in the evolution of Microsporidia intracellular parasites.
(Springer Nature, 2018-04-27)The acquisition of genes by horizontal transfer can impart entirely new biological functions and provide an important route to major evolutionary innovation. Here we have used ancient gene reconstruction and functional ... -
Linear mitochondrial DNA is rapidly degraded by components of the replication machinery.
(Springer Nature, 2018-04-30)Emerging gene therapy approaches that aim to eliminate pathogenic mutations of mitochondrial DNA (mtDNA) rely on efficient degradation of linearized mtDNA, but the enzymatic machinery performing this task is presently ...
