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  An inhibitor of oxidative phosphorylation exploits cancer vulnerability. 

  Molina, Jennifer R; Sun, Yuting; Protopopova, Marina; Gera, Sonal; Bandi, Madhavi; Bristow, Christopher; McAfoos, TimothyMorlacchi, PietroAckroyd, JeffreyAgip, Ahmed-Noor AAl-Atrash, GheathAsara, JohnBardenhagen, JenniferCarrillo, Caroline CCarroll, ChristopherChang, EdwardCiurea, StefanCross, Jason BCzako, BarbaraDeem, AngelaDaver, Navalde Groot, John FrederickDong, Jian-WenFeng, NingpingGao, GuangGay, JasonDo, Mary GeckGreer, JenniferGiuliani, VirginiaHan, JingHan, LinaHenry, Verlene KHirst, JudyHuang, ShaJiang, YongyingKang, ZhijunKhor, TinKonoplev, SergejLin, Yu-HsiLiu, GangLodi, AlessiaLofton, TimothyMa, HelenMahendra, MikhilaMatre, PolinaMullinax, RobertPeoples, MichaelPetrocchi, AlessiaRodriguez-Canale, JaimeSerreli, RiccardoShi, ThomasSmith, MelindaTabe, YokoTheroff, JayTiziani, StefanoXu, QuanyunZhang, QiMuller, FlorianDePinho, Ronald AToniatti, CarloDraetta, Giulio FHeffernan, Timothy PKonopleva, MarinaJones, PhilipDi Francesco, M EmiliaMarszalek, Joseph R et al. (Springer Nature, 2018-06-11)

  Metabolic reprograming is an emerging hallmark of tumor biology and an actively pursued opportunity in oncology drug discovery. Extensive efforts have focused on therapeutic targeting of glycolysis, whereas drugging ...
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  SURF1 knockout cloned pigs: Early onset of a severe lethal phenotype. 

  Quadalti, C; Brunetti, D; Lagutina, I; Duchi, R; Perota, A; Lazzari, G; Cerutti, RDi Meo, IJohnson, MBottani, ECrociara, PCorona, CGrifoni, STiranti, VFernandez-Vizarra, ERobinson, Alan JonathanViscomi, Carlo FioreCasalone, CZeviani, MGalli, C et al. (Elsevier, 2018-06)

  Leigh syndrome (LS) associated with cytochrome c oxidase (COX) deficiency is an early onset, fatal mitochondrial encephalopathy, leading to multiple neurological failure and eventually death, usually in the first decade ...
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  Lifelong Reduction in Complex IV Induces Tissue Specific Metabolic Effects But Does Not Reduce Lifespan or Healthspan in Mice 

  Viscomi, Carlo Fiore (Wiley-Blackwell, 2018-04-25)

  Loss of SURF1, a Complex IV assembly protein, was reported to increase lifespan in mice despite dramatically lower cytochrome oxidase (COX) activity. Consistent with this, our previous studies found advantageous changes ...
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  Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development. 

  Phillips, Tom J; Scott, Hannah; Menassa, David A; Bignell, Ashleigh L; Sood, Aman; Morton, Jude S; Akagi, TakamiAzuma, KokiRogers, Mark FGilmore, Catherine EInman, Gareth JGrant, SimonChung, YealinAljunaidy, Mais MCooke, Christy-LynnSteinkraus, Bruno RPocklington, AndrewLogan, AngelaCollett, Gavin PKemp, HelenaHolmans, Peter AMurphy, Michael PatrickFulga, Tudor AConey, Andrew MAkashi, MitsuruDavidge, Sandra TCase, C Patrick et al. (2017-08-22)

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