MRC Mitochondrial Biology Unit
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Expression and putative role of mitochondrial transport proteins in cancer
(Elsevier, 2016-12-14)Cancer cells undergo major changes in energy and biosynthetic metabolism. One of them is the Warburg effect, in which pyruvate is used for fermentation rather for oxidative phosphorylation. Another major one is their ... -
The Enigma of the Respiratory Chain Supercomplex
(Elsevier (Cell Press), 2017-04-04)Respiratory chain dysfunction plays an important role in human disease and aging. It is now well established that the individual respiratory complexes can be organized into supercomplexes, and structures for these ... -
The mitochondria–endoplasmic reticulum contact sites: a signalling platform for cell death
(Elsevier, 2017-08-01)Mitochondria evolved as an endosymbiont providing the cell with a dizzying array of catabolic and anabolic processes essential for life. However, mitochondria have retained the ability to kill from within, and are widely ... -
Dealing with an Unconventional Genetic Code in Mitochondria: The Biogenesis and Pathogenic Defects of the 5‐Formylcytosine Modification in Mitochondrial tRNA$^{Met}$
(MDPI, 2017-03-02)Human mitochondria contain their own genome, which uses an unconventional genetic code. In addition to the standard AUG methionine codon, the single mitochondrial tRNA Methionine (mt‐tRNA$^{Met}$) also recognises AUA during ...
