MRC Mitochondrial Biology Unit
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Identification and characterisation of new factors and mechanisms regulating human cytochrome c oxidase biogenesis
(2019-05-18)Assembly of the mitochondrial complex IV (CIV) or cytochrome c oxidase (COX) is an intricate and highly regulated process in which the three-core mitochondrial DNA (mtDNA) encoded subunits assemble in a coordinated way ... -
Developing drugs to attenuate succinate accumulation and oxidation
(2019-04-27)Ischaemia-reperfusion (IR) injury is caused by the re-introduction of oxygen to organs, following periods of reduced blood flow (ischaemia). Whilst re-establishing blood flow (reperfusion) to the heart following myocardial ... -
Studies on assembly and genetic variation in mitochondrial respiratory complex I
(2019-03-30)Complex I (NADH:ubiquinone oxidoreductase) couples electron transfer to proton translocation across the inner mitochondrial membrane, to drive the synthesis of ATP. Its distinctive L-shaped structure comprises 45 subunits, ... -
Comparative phylogenetic exploration of the human mitochondrial proteome: Insights into disease and metabolism
(2019-02-23)Mitochondria are a key organelle within human cells, with functions ranging from ATP synthesis to apoptosis. Changes in mitochondrial function are associated with many diseases, as well as ‘natural’ processes like ageing. ...
