MRC Mitochondrial Biology Unit
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Investigations of the mechanism of mitochondrial complex I by electron cryomicroscopy
Mitochondria are double membrane-bound organelles found in the cytosol of eukaryotic cells. They generate energy for the cell by oxidising the breakdown products of metabolism and relaying the liberated electrons through ... -
Functional characterisation of the human mitochondrial ATP-Mg/Pi carriers and their disease-causing variants
The mitochondrial ATP-Mg/Pi carriers (APCs) catalyses the exchange of adenine nucleotides for phosphate across the mitochondrial inner membrane, which is regulated by calcium. They are responsible for modulating the adenine ... -
Identification and functional characterisation of different inner mitochondrial membrane supercomplexes
The inner mitochondria membrane (IMM) is densely packed with proteins necessary for mitochondrial activity, including oxidative phosphorylation (OXPHOS) complexes and transporters. Mitochondrial respiratory chain (MRC) ... -
Characterisation of new factors regulating mitochondrial dynamics and cellular metabolism
Mitochondria are dynamic organelles that possess an inherent plasticity which governs their shape, size and distribution. This dynamic behaviour depends on continuous cycles of fission or fusion, which is mediated by large ...
