MRC Mitochondrial Biology Unit
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Human METTL12 is a mitochondrial methyltransferase that modifies citrate synthase
The protein methylome in mammalian mitochondria has been little studied until recently. Here, we describe that lysine-368 of human citrate synthase is methylated and that the modifying enzyme, localized in the mitochondrial ... -
Oxidation state-dependent binding properties of the active site in a Mo-containing formate dehydrogenase
(American Chemical Society, 2017-06-21)Molybdenum-containing formate dehydrogenase H from Escherichia coli (EcFDH-H) is a powerful model system for studies of the reversible reduction of CO2 to formate. However, the mechanism of FDH catalysis is currently ... -
Assessment of H$_{2}$S in vivo using the newly developed mitochondria-targeted mass spectrometry probe MitoA
(American Society for Biochemistry and Molecular Biology Inc., 2017-05-12)Hydrogen sulfide (H$_{2}$S) is produced endogenously in vivo and has multiple effects on signaling pathways and cell function. Mitochondria can be both an H$_{2}$S source and sink, and many of the biological effects of ... -
Expression and putative role of mitochondrial transport proteins in cancer
(Elsevier, 2017-08-01)Cancer cells undergo major changes in energy and biosynthetic metabolism. One of them is the Warburg effect, in which pyruvate is used for fermentation rather for oxidative phosphorylation. Another major one is their ...
