MRC Mitochondrial Biology Unit
About this community
Collections in this community
Recent Submissions
-
Mitochondrial dysfunction during ischaemia reperfusion injury in models of organ transplantation
Organ transplantation is the only treatment for patients with severe and irreversible organ damage. Although the efficacy of transplantation has progressed immensely in recent years, one of the most damaging factors occurring ... -
The role of RNA modifications in mitochondrial translation
(2020-07-31)Mitochondrial gene expression entails multiple steps, one of which is translation, performed by the mitochondrial ribosome. Post-transcriptional RNA nucleotide modifications have been identified in mitochondrial (mt)-rRNAs. ... -
The Molecular Anatomy of Mitochondrial Disease: Identification and Characterisation of Novel Nuclear-Encoded Mitochondrial Disease Genes
Mitochondrial diseases are a group of clinically and genetically heterogeneous disorders typically associated with abnormal oxidative phosphorylation (OXPHOS). In recent years, next generation sequencing technologies have ... -
Genetic characterisation of the Drosophila Mitochondrial Calcium Uniporter in physiological and neurodegenerative contexts
Neurodegenerative conditions such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are a growing medical and social burden for which no disease-modifying therapies exist, necessitating greater understanding of their ...
