MRC Mitochondrial Biology Unit
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The role of RNA modifications in mitochondrial translation
(2020-07-31)Mitochondrial gene expression entails multiple steps, one of which is translation, performed by the mitochondrial ribosome. Post-transcriptional RNA nucleotide modifications have been identified in mitochondrial (mt)-rRNAs. ... -
The Molecular Anatomy of Mitochondrial Disease: Identification and Characterisation of Novel Nuclear-Encoded Mitochondrial Disease Genes
Mitochondrial diseases are a group of clinically and genetically heterogeneous disorders typically associated with abnormal oxidative phosphorylation (OXPHOS). In recent years, next generation sequencing technologies have ... -
Genetic characterisation of the Drosophila Mitochondrial Calcium Uniporter in physiological and neurodegenerative contexts
Neurodegenerative conditions such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are a growing medical and social burden for which no disease-modifying therapies exist, necessitating greater understanding of their ... -
Chemical Strategies for Delivery of Compounds to Mitochondria
(2019-11-30)Mitochondria are involved in numerous processes vital for cellular homeostasis, therefore, mitochondrial dysfunction can lead to a wide range of diseases. Understanding mitochondrial function in health and disease is crucial ...
