MRC Mitochondrial Biology Unit
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(Springer Nature, 2018-06-11)Metabolic reprograming is an emerging hallmark of tumor biology and an actively pursued opportunity in oncology drug discovery. Extensive efforts have focused on therapeutic targeting of glycolysis, whereas drugging ...
(Elsevier, 2018-06)Leigh syndrome (LS) associated with cytochrome c oxidase (COX) deficiency is an early onset, fatal mitochondrial encephalopathy, leading to multiple neurological failure and eventually death, usually in the first decade ...
Lifelong Reduction in Complex IV Induces Tissue Specific Metabolic Effects But Does Not Reduce Lifespan or Healthspan in Mice (Wiley-Blackwell, 2018-04-25)Loss of SURF1, a Complex IV assembly protein, was reported to increase lifespan in mice despite dramatically lower cytochrome oxidase (COX) activity. Consistent with this, our previous studies found advantageous changes ...