MRC Mitochondrial Biology Unit
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How Detergent Impacts Membrane Proteins: Atomic-Level Views of Mitochondrial Carriers in Dodecylphosphocholine.
(American Chemical Society, 2018-03)Characterizing membrane protein (MP) structure generally requires extraction from their native membrane, most commonly with detergents. The physico-chemical properties of detergent micelles and lipid bilayers differ markedly. ... -
Major concerns with the integrity of the mitochondrial ADP/ATP carrier in dodecyl-phosphocholine used for solution NMR studies
Hereby, we wish to note our objections to a paper called "Substrate-modulated ADP/ATP-transporter dynamics revealed by NMR relaxation dispersion" by Brüschweiler et al., published in NSMB in 20151. The subject is the yeast ... -
Assembly of the membrane domain of ATP synthase in human mitochondria.
(National Academy of Sciences, 2018-03)The ATP synthase in human mitochondria is a membrane bound assembly of 29 proteins of 18 kinds. All but two membrane components are encoded in nuclear genes, synthesized on cytoplasmic ribosomes and imported into the matrix ... -
Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase.
(National Academy of Sciences, 2017-03-28)The permeability transition in human mitochondria refers to the opening of a nonspecific channel, known as the permeability transition pore (PTP), in the inner membrane. Opening can be triggered by calcium ions, leading ...
