MRC Mitochondrial Biology Unit
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Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase (National Academy of Sciences, 2017-08-22)The opening of a non-specific channel, known as the permeability transition pore (PTP), in the inner membranes of mitochondria, can be triggered by calcium ions, leading to swelling of the organelle, disruption of the inner ...
Mitochondria-targeted antioxidant MitoQ reduced renal damage caused by ischemia-reperfusion injury in rodent kidneys: Longitudinal observations of T2 -weighted imaging and dynamic contrast-enhanced MRI. (Wiley-Blackwell, 2017-06-12)PURPOSE: To investigate the effect of mitochondria-targeted antioxidant MitoQ in reducing the severity of renal ischemia-reperfusion injury (IRI) in rats using T2 -weighted imaging and dynamic contrast-enhanced MRI (DCE-MRI). ...