MRC Mitochondrial Biology Unit
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Using molecular approaches to understand Complex I deficiency in mouse models
Complex I (NADH:ubiquinone oxidoreductase), a major electron entry point to the mitochondrial respiratory chain, couples electron transfer from NADH to ubiquinone to proton pumping across the mitochondrial inner membrane, ... -
Expression, Purification and Molecular Characterisation of Sideroflexin Proteins
(2021-05-01)Members of the sideroflexin family are poorly characterised membrane proteins of the mitochondrial inner membrane. Understanding their function is now a high priority, as patients have been identified who carry mutations ... -
Analysis of PINK1/Parkin-related mitochondrial quality control in Drosophila
Mitochondria are essential organelles that perform many critical metabolic functions but are also a major source of damaging reactive oxygen species (ROS) and harbour pro-apoptotic factors. Multiple homeostatic processes ... -
Investigations of the mechanism of mitochondrial complex I by electron cryomicroscopy
Mitochondria are double membrane-bound organelles found in the cytosol of eukaryotic cells. They generate energy for the cell by oxidising the breakdown products of metabolism and relaying the liberated electrons through ...
