MRC Laboratory of Molecular Biology
Recent Submissions
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Determination of the Composition and Architecture of the Mitochondrial Ubiquitome in PINK1/Parkin Mitophagy
Parkinson’s Disease is the second most common age-related neurodegenerative disorder, with multiple lines of evidence suggesting that mitochondrial dysfunction may underlie the etiology of the disease. The kinase PINK1, ... -
Activation of lipid kinase VPS34 by Rab GTPases
VPS34 is a lipid kinase that uses phosphatidylinositol (PI) as a substrate to produce the signalling lipid phosphatidylinositol-3-phosphate (PI(3)P). In the cell, VPS34 has to team up with other proteins in order to increase ... -
Investigating the trafficking of Golgi-resident glycosylation enzymes
The Golgi is a major site of glycan processing mediated by a large number of Golgi-resident glycosylation enzymes. These enzymes are largely type II transmembrane domain (TMD) proteins consisting of a short N-terminal ... -
Identification of novel regulators of lymphocyte development and differentiation using CRISPR-Cas9 screens
T helper-2 (TH2) and type 2 innate lymphoid cells (ILC2s) play important roles in parasite expulsion, wound healing and allergic diseases through the expression of type 2 cytokines including IL-4, IL-5 and IL-13. Central ...
