MRC Laboratory of Molecular Biology
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(2018-07-20)Protein ubiquitination regulates various cellular events, such as protein degradation, immune signalling and DNA repair. This functional versatility arises from the ability of ubiquitin (Ub) to form distinct polymers linked ...
(2018-01-22)The pathological hallmark of many age-related neurodegenerative diseases is the presence of proteinaceous inclusions in nerve cells and glial cells. Alpha-synuclein is the main component of the inclusions of Parkinson’s ...
(2018-07-20)Ubiquitin phosphorylation by PINK1 (PTEN-induced Putative Kinase 1) is crucial for mitochondrial quality control and loss or mutation of PINK1 can lead to autosomal recessive juvenile parkinsonism (AR-JP). PINK1 is an ...