MRC Laboratory of Molecular Biology
Recent Submissions
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Molecular recognition of aberrant translation
(2019-11-30)Protein translation is a fundamental, demanding process which requires several million ribosomes and consumes as much as 75% of cellular energy. Because of its importance, translation is regulated at many levels to maintain ... -
Structural studies of trans-translation
(2019-10-26)Ribosomes translate messenger RNA (mRNA) into protein in all living cells. The faultless production of protein is critical for a vast array of catalytic and structural roles and is essential for the survival of the cell. ... -
A screen for novel interactions within the vertebrate centriole
(2019-09-30)The centrioles organize the centrosomes and cilia which play a role in cell division, motility, sensing, polarity, trafficking and signalling. There has been an increase in the understanding of centriole composition and ... -
Architecture of eukaryotic mRNA 3' end processing machinery and insights into the mechanism of polyadenylation
(2019-11-30)Almost all eukaryotic messenger RNAs (mRNAs) have a polyadenosine (polyA) tail at their 3′ end that is added by a multi-protein complex known as cleavage and polyadenylation factor (CPF). CPF, along with accessory cleavage ...
