MRC Laboratory of Molecular Biology
Recent Submissions
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MECHANISM OF PINK1-MEDIATED UBIQUITIN PHOSPHORYLATION
(2018-07-20)Ubiquitin phosphorylation by PINK1 (PTEN-induced Putative Kinase 1) is crucial for mitochondrial quality control and loss or mutation of PINK1 can lead to autosomal recessive juvenile parkinsonism (AR-JP). PINK1 is an ... -
Structural and Functional Characterisation of the Nutrient Sensing Kinase GCN2
(2018-07-20)A cell’s ability to recognise and respond to changes in its environment is crucial to its survival. The availability of nutrients is a fundamental part of the environment, and so cells must be able to identify when they ... -
Membrane protein biosynthesis at the endoplasmic reticulum
(2018-07-20)The biosynthesis of integral membrane proteins (IMPs) is an essential cellular process. IMPs comprise roughly 20-30% of the protein coding genes of all organisms, nearly all of which are inserted and assembled at the ... -
Single-molecule studies of bacterial DNA replication and translesion synthesis
(2018-07-21)Faithful replication of genomic DNA is crucial for the survival of a cell. In order to achieve high-level accuracy in copying its genome, all cells employ replicative DNA polymerases that have intrinsic high fidelity. When ...
