Theses - MRC Laboratory of Molecular Biology
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Recent Submissions
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Molecular Mechanisms Involved in Chromosome Segregation
Eukaryotic organisms use large and intricate macromolecular machines to accurately pass chromosomes to two daughter cells during cell division. Errors during chromosome segregation are frequently deleterious to the cell ... -
In vitro reconstitution of the human pre-mRNA 3′ end processing machinery and mechanistic insights into endonuclease activation
Maturation of protein-coding transcripts in eukaryotes involves several processing steps, including 5′ capping, splicing, and 3′ end processing. The latter entails endonucleolytic cleavage of the nascent pre-mRNA and ... -
Translational tuning pre-emptively modulates protein folding and secretory pathway defects
Cells use multiple mechanisms to ensure the accurate synthesis of the proteome, including translational and post-translational regulation. My thesis investigates how translation can be modulated to pre-emptively protect ... -
Towards structural characterisation of ciliary rootlets, ciliary caps and intraflagellar transport
Cilia elongation and homeostasis require the transport of building blocks and signalling molecules between the ciliary base and tip through a process called intraflagellar transport (IFT). IFT is driven by multiple copies ...
