Theses - MRC Laboratory of Molecular Biology
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Functional analysis of Shigella encoded IpaH E3 ubiquitin ligases in cell-autonomous immunity
Shigella flexneri is a highly adapted pathogen that invades the host cytosol and causes bacillary dysentery. Shigella has evolved powerful countermeasures to disarm host defense mechanisms; amongst them a family of twelve ... -
STUDIES IN OOCYTES FROM THREE MAMMALIAN SPECIES DEMONSTRATE THAT MEIOTIC KINETOCHORES ARE COMPOSED OF PREVIOUSLY UNIDENTIFIED SUBDOMAINS AND REVEAL TWO NOVEL MECHANISMS BEHIND THE MATERNAL-AGE EFFECT IN HUMANS
(2020-06-14)Poor egg quality is the leading cause of pregnancy loss and Down’s syndrome. While even eggs in young women frequently contain an incorrect number of chromosomes and are therefore unlikely to give rise to a viable pregnancy, ... -
Protein Shape Description and its Application to Shape Comparison
(2018-11-24)There are currently over 138, 000 known macromolecular structures deposited in the wwPDB (Worldwide Protein Data Bank) database. While all the macromolecular structure files contain information about a particular structure, ... -
Sorting of membrane proteins in the yeast secretory pathway
(1997-07-11)
