Theses - MRC Laboratory of Molecular Biology
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Development of in vitro iCLIP techniques to study spliceosome remodelling by RNA helicases
(2019-04-30)Pre-mRNA (precursor messenger RNA) splicing is a fundamental process in eukaryotic gene expression. In order to catalyse the excision of the intervening intronic sequence between two exons, the spliceosome is assembled ... -
Probing RNA binding specificities of AID/APOBEC proteins by iCLIP
(2019-01-31)The AID/APOBEC protein family comprises a group of cytosine deaminases found in vertebrates that are capable of modifying cytosine to uracil in the context of RNA or singlestranded DNA. They exert diverse valuable physiological ... -
CHARACTERISATION OF A NOVEL SPINDLE DOMAIN IN MAMMALIAN MEIOSIS
(2019-05-18)The organisation of microtubule networks into a bipolar spindle is essential for reliable chromosome segregation during cell division. A pair of centrioles surrounded by pericentriolar material (PCM), define the canonical ... -
Functional analysis of Shigella encoded IpaH E3 ubiquitin ligases in cell-autonomous immunity
Shigella flexneri is a highly adapted pathogen that invades the host cytosol and causes bacillary dysentery. Shigella has evolved powerful countermeasures to disarm host defense mechanisms; amongst them a family of twelve ...
