Theses - MRC Laboratory of Molecular Biology
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Recent Submissions
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Evolution and Engineering of RNA-based Macromolecular Machines
The “RNA World Hypothesis” posits that extant life was likely preceded by a simpler primordial biology lacking DNA and proteins, relying instead on RNA for both heredity and catalysis. An essential component of an RNA world ... -
In vitro reconstitution of Central Spindle Motility
Precise localisation of intracellular organelles impacts a myriad of cellular processes including cell motility, polarisation and mitosis. Positioning is actively controlled by organelle specific attachment, often involving ... -
The physical origins of specimen movement in electron cryomicroscopy and how to eliminate it
Electron cryomicroscopy (cryoEM) is an important imaging technique for determining the atomic structures of biological macromolecules and complexes. Success in determining a structure by cryoEM depends on being able to ... -
Genetic interactions of repriming and translesion synthesis
PRIMPOL is the only known eukaryotic primase outside of the core replisome. It has been previously shown to restart DNA synthesis past replication impediments such as DNA damage or non-B-DNA secondary structures. To probe ...
