Theses - MRC Laboratory of Molecular Biology

Specific Recognition of Atypical Ubiquitin Modifications

Michel, Martin Alex (2018-07-20)

Protein ubiquitination regulates various cellular events, such as protein degradation, immune signalling and DNA repair. This functional versatility arises from the ability of ubiquitin (Ub) to form distinct polymers linked ...
The prion-like properties of assembled human alpha-synuclein

Morgan, Sophie (2018-01-22)

The pathological hallmark of many age-related neurodegenerative diseases is the presence of proteinaceous inclusions in nerve cells and glial cells. Alpha-synuclein is the main component of the inclusions of Parkinson’s ...
Thermostabilisation of the human CRF1 receptor in the presence of an agonist and a G protein

Strege, Annette (2018-09-22)
MECHANISM OF PINK1-MEDIATED UBIQUITIN PHOSPHORYLATION

Schubert, Alexander Fabian (2018-07-20)

Ubiquitin phosphorylation by PINK1 (PTEN-induced Putative Kinase 1) is crucial for mitochondrial quality control and loss or mutation of PINK1 can lead to autosomal recessive juvenile parkinsonism (AR-JP). PINK1 is an ...