Theses - MRC Laboratory of Molecular Biology
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Recent Submissions
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Structure/Function Studies on Vps9 domain-containing Ankyrin Repeat protein (VARP)
Vps-9 domain ankyrin repeat protein (Varp) is a widely expressed multi- domain protein of 1050 amino acids that resides in the cytosol. Varp has been shown to be a Rab21 GEF, a Rab32/38 effector and also helps to regulate ... -
The identification of novel factors required for the development of primordial germ cells
(2020-04-25)DNA is constantly exposed to both exogenous and endogenous sources of DNA damage. Therefore, organisms evolved a plethora of DNA repair pathways to repair these distinct lesions and prevent mutations from arising. Mutations ... -
TRIM21 Mediated Antibody-Dependent Intracellular Immunity
(2020-05-16)Antibodies have been extensively studied since the 1890s, revealing their importance in protective immunity and allowing their development in numerous research and therapeutic applications. However, these studies have ... -
Characterisation of new regulators and neural plasticity of the O2-sensing circuit in Caenorhabditis elegans
(2020-05-16)Oxygen is the main sensory stimulus that promotes aggregation and elicits O2- escape behaviour in C. elegans. It also constitutes a salient cue for this nematode that reprograms its behavioural strategies as well as ...
