Theses - MRC Laboratory of Molecular Biology
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Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response
The genome is subjected to many forms of attack that can compromise its stability. Such forms of attack can emerge from endogenous or exogenous sources and must be counteracted by specialised repair pathways. Indeed, the ... -
Investigating the roles of IL-25, IL-33 and ILC2s in APC-mutation-mediated colorectal cancer
Interleukin-25 (IL-25) and group 2 innate lymphoid cells (ILC2s) play critical roles in the host immune defense against intestinal parasitic helminth infections, through orchestrating the protective type 2 immune response, ... -
Mechanism of anaesthetic activation, combination and antagonism
The type A γ-aminobutyric acid receptors (GABAAR) – pentameric ligand gated ion channels (pLGICs) – are the main mediators of fast inhibitory neurotransmission in the human brain. Malfunctions in these receptors are a ... -
NMR Studies of the RNA Binding Domain of U1A protein and its Complexes with RNA
(1996-01-04)Eukaryotic splicing is catalysed by five RNA protein complexes called snRNP's. U1A is one protein component of the U1 snRNP particle. The role of U1A in splicing is unclear, but it does bind a hairpin loop from U1 RNA. U1A ...
