Theses - MRC Laboratory of Molecular Biology
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Identification of novel regulators of lymphocyte development and differentiation using CRISPR-Cas9 screens
T helper-2 (TH2) and type 2 innate lymphoid cells (ILC2s) play important roles in parasite expulsion, wound healing and allergic diseases through the expression of type 2 cytokines including IL-4, IL-5 and IL-13. Central ... -
The proteasome and its ancillary proteins
(2020-09-29)The proteasome is an essential multi-protein complex found within all eukaryotes. It degrades unwanted proteins and is involved in regulating many cellular functions, including cell homeostasis and apoptosis. Previous ... -
Investigating Anatomical and Neurochemical Topology of the Mammalian Suprachiasmatic Nucleus
Precise, robust and entrained circadian timing of bodily functions down to the cellular and molecular scale is pivotal for ensuring efficient use of resources by an organism in pursuit of optimal evolutionary fitness. In ... -
Towards Enzymatic Synthesis of Uncharged Xeno Nucleic Acids
A genetic material is a defining requirement for life. The many practical uses of DNA and RNA have also made these molecules integral tools for human manipulation of biological systems. However, high susceptibility to ...
