Theses - MRC Laboratory of Molecular Biology
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Probing RNA binding specificities of AID/APOBEC proteins by iCLIP
(2019-01-31)The AID/APOBEC protein family comprises a group of cytosine deaminases found in vertebrates that are capable of modifying cytosine to uracil in the context of RNA or singlestranded DNA. They exert diverse valuable physiological ... -
CHARACTERISATION OF A NOVEL SPINDLE DOMAIN IN MAMMALIAN MEIOSIS
(2019-05-18)The organisation of microtubule networks into a bipolar spindle is essential for reliable chromosome segregation during cell division. A pair of centrioles surrounded by pericentriolar material (PCM), define the canonical ... -
Functional analysis of Shigella encoded IpaH E3 ubiquitin ligases in cell-autonomous immunity
Shigella flexneri is a highly adapted pathogen that invades the host cytosol and causes bacillary dysentery. Shigella has evolved powerful countermeasures to disarm host defense mechanisms; amongst them a family of twelve ... -
STUDIES IN OOCYTES FROM THREE MAMMALIAN SPECIES DEMONSTRATE THAT MEIOTIC KINETOCHORES ARE COMPOSED OF PREVIOUSLY UNIDENTIFIED SUBDOMAINS AND REVEAL TWO NOVEL MECHANISMS BEHIND THE MATERNAL-AGE EFFECT IN HUMANS
(2020-06-14)Poor egg quality is the leading cause of pregnancy loss and Down’s syndrome. While even eggs in young women frequently contain an incorrect number of chromosomes and are therefore unlikely to give rise to a viable pregnancy, ...
