Theses - MRC Laboratory of Molecular Biology
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Recent Submissions
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Mechanisms of molecular switching in the Wnt signal transduction pathway
(2018-11-24)Wnt signalling is a critical cellular communication pathway controlling cell fate in all metazoan organisms. Timely activation of this pathway is crucial to coordinate development, control homeostasis of adult tissues, and ... -
Helical Reconstruction in RELION
(2018-11-24)Helical assemblies of proteins are ubiquitous in nature and they perform vital functions in a wide range of organisms. The recent development of direct electron detectors and other imaging techniques in cryo-electron ... -
Novel detection and evasion mechanisms pertinent to immunity against Salmonella Typhimurium
(2018-10-20)Cells defend their cytosol against pathogen invasion using cell-autonomous immunity. When pathogens enter the cytosol they can damage host endomembranes, causing the mislocalisation of host molecules not normally found in ... -
Specific Recognition of Atypical Ubiquitin Modifications
(2018-07-20)Protein ubiquitination regulates various cellular events, such as protein degradation, immune signalling and DNA repair. This functional versatility arises from the ability of ubiquitin (Ub) to form distinct polymers linked ...
