Theses - MRC Laboratory of Molecular Biology
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Recent Submissions
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A New Approach To Identifying Effectors and Regulators of Small GTPases
Secretion and endocytosis are essential processes in eukaryotic cells, executed and tightly regulated by the cell’s endomembrane system. It is widely accepted that small GTPases of the Ras superfamily are major regulators ... -
Structural studies of the mitochondrial ribosome and co-translational insertion of membrane proteins
The mitochondrion, a constituent of eukaryotic cells is important in the synthesis of ATP through a process called oxidative phosphorylation. The enzymes that make up the subunits of oxidative phosphorylation in humans and ... -
Characterising molecular and cellular mechanisms of human brain evolution using brain organoids
The evolutionary lineage of humans is marked by a rapid expansion in brain size. Efforts to study human brain evolution have characteristically relied on anatomical and genomic comparisons between adult ape brains, meaning ... -
Functional and behavioural characterisation of C. elegans acid-sensing DEG/ENaCs
The overarching aim of this thesis was to investigate how proton-sensitive members of the C. elegans DEG/ENaC family regulate cellular processes and drive behaviour. In the initial screen, I identified five C. elegans ...
