Theses - MRC Laboratory of Molecular Biology
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DNA crosslink repair safeguards genomic stability during pre-meiotic germ cell development
Germ cells are single-handedly responsible for the transmission of genetic and epigenetic information (the instructions to make new life) from one generation to the next. It is therefore, of paramount importance that germ ... -
Visualisation of dynein complexes in vitro and inside cells
Proper neuronal function relies on efficient transport within axons and dendrites, the long processes which extend from neuronal cell bodies. Within neuronal processes, the microtubule cytoskeleton provides tracks for ... -
Genetic analysis of dynein function in the nervous system and in mitosis
Cytoplasmic dynein-1 is an essential microtubule-based molecular motor. Aided by several adaptors and co-factors, dynein orchestrates retrograde transport of diverse cargoes in interphase cells and plays multiple roles in ... -
The function of golgin vesicle tethers in Drosophila melanogaster
Accurate membrane targeting is essential for the organisation of membrane traffic. This step is particularly crucial at the Golgi apparatus, a central sorting hub of membrane traffic in the cell. Golgins, a class of highly ...
