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dc.contributor.authorMalhotra, Sen
dc.contributor.authorMugumbate, Gen
dc.contributor.authorBlundell, Tomen
dc.contributor.authorHigueruelo, APen
dc.date.accessioned2017-05-25T14:25:23Z
dc.date.available2017-05-25T14:25:23Z
dc.identifier.issn1758-0463
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/264432
dc.description.abstractTIBLE is a web-based resource that provides easy access to data on the minimal inhibitory concentrations for small molecules against several mycobacterial species, as well as the target binding and off-target predictions for Mycobacterium tuberculosis. The current version of the database holds the activity data for more than 19 000 distinct small molecules against 39 mycobacterial species, binding data for 106 Mycobacterium tuberculosis target proteins and predictions for their potential off-targets. The resource integrates disparate public data and methods to provide easy access to the minimum inhibitory concentration and binding data, facilitation of data sharing, and identification of small molecules and targets for development of anti-tuberculosis therapeutics.
dc.description.sponsorshipWellcome Trust Seeding Drug Discovery (101134/Z/13/Z to A.P.H., T.L.B.); MRC Newton Award (RG78439 to S.M. and T.L.B.); Programme Grant (093167/Z/10/Z to T.L.B.); Cystic Fibrosis Trust Grant (RG 70975); Wellcome Trust Investigator Award (200814/Z/16/Z to T.L.B.).
dc.language.isoenen
dc.publisherOxford University Press
dc.titleTIBLE: a web-based, freely accessible resource for small-molecule binding data for mycobacterial speciesen
dc.typeArticle
prism.numberbax041en
prism.publicationNameDatabase : the Journal of Biological Databases and Curationen
prism.volume2017en
dc.identifier.doi10.17863/CAM.9909
dcterms.dateAccepted2017-04-25en
rioxxterms.versionofrecord10.1093/database/bax041en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-04-25en
dc.contributor.orcidBlundell, Tom [0000-0002-2708-8992]
dc.identifier.eissn1758-0463
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (200814/Z/16/Z)
pubs.funder-project-idWellcome Trust (093167/Z/10/Z)
pubs.funder-project-idWellcome Trust (101134/Z/13/Z)
pubs.funder-project-idMRC (MR/M026302/1)
pubs.funder-project-idMedical Research Council (MR/N501864/1)
cam.issuedOnline2017-06-11en
dc.identifier.urlhttps://academic.oup.com/database/article/doi/10.1093/database/bax041/3866794en
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