Nomenclature and definition in asymmetric regional body overgrowth
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Peer-reviewed
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Abstract
We designate a novel term “isolated lateralized overgrowth” (ILO) for the findings previously described as “isolated hemihypertrophy” and “isolated hemihyperplasia.” ILO is defined as lateralized overgrowth in the absence of a recognized pattern of malformations, dysplasia, or morphologic variants. ILO is likely genetically heterogeneous. Further study is required to determine more of the underlying genetic etiologies and potential associations with currently unrecognized patterns of malformation.
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Keywords
Beckwith-Wiedemann syndrome, isolated hemihyperplasia, isolated hemihypertrophy, isolated lateralized overgrowth, isolated unilateral overgrowth, lateralized overgrowth, segmental overgrowth
Journal Title
American Journal of Medical Genetics, Part A
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Journal ISSN
1552-4825
1552-4833
1552-4833
Volume Title
173
Publisher
Wiley-Liss Inc
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Sponsorship
National Cancer Institute, Grant number: K08CA193915; Alex’s Lemonade Stand Foundationfor Childhood Cancer; St. Baldrick’s Foundation