Show simple item record

dc.contributor.authorSun, Qianen
dc.contributor.authorDu, Yaoen
dc.contributor.authorZhao, Zen
dc.contributor.authorHall, Lisaen
dc.contributor.authorGao, Hen
dc.contributor.authorSukhorukov, GBen
dc.contributor.authorRouth, Alexen
dc.date.accessioned2017-06-30T16:47:46Z
dc.date.available2017-06-30T16:47:46Z
dc.identifier.issn0743-7463
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/265113
dc.description.abstractColloidosomes have attracted great interest in recent years because of their capability for storage and delivery of small molecules for medical and pharmaceutical applications. However, traditional polymer shell colloidosomes leak low molecular weight drugs due to their intrinsic shell permeability. Here, we report aqueous core colloidosomes with a silver shell, which seals the core and makes the shell impermeable. The silver-coated colloidosomes were prepared by reacting l-ascorbic acid in the microcapsule core with silver nitrate in the wash solution. The silver shell colloidosomes were then modified by using 4,4′-dithiodibutyric acid and cross-linked with rabbit Immunoglobulin G (IgG). Label-free surface plasmon resonance was used to test the specific targeting of the functional silver shell with rabbit antigen. To break the shells, ultrasound treatment was used. The results demonstrate that a new type of functional silver-coated colloidosome with immunoassay targeting, nonpermeability, and ultrasound sensitivity could be applied to many medical applications.
dc.description.sponsorshipQian Sun, Ziyan Zhao, and Hui Gao are grateful to the China Scholarship Council for funding. Yao Du is grateful to the Agency for Science Technology and Research (A*STAR) Singapore for funding.
dc.languageengen
dc.language.isoenen
dc.publisherAmerican Chemical Society
dc.titleFunctional Silver-Coated Colloidosomes as Targeted Carriers for Small Moleculesen
dc.typeArticle
prism.endingPage3764
prism.issueIdentifier15en
prism.publicationNameLangmuiren
prism.startingPage3755
prism.volume33en
dc.identifier.doi10.17863/CAM.11025
dcterms.dateAccepted2017-03-29en
rioxxterms.versionofrecord10.1021/acs.langmuir.6b04594en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-03-29en
dc.contributor.orcidSun, Qian [0000-0002-5192-3599]
dc.contributor.orcidHall, Lisa [0000-0001-9572-9854]
dc.contributor.orcidRouth, Alex [0000-0002-3443-3053]
dc.identifier.eissn1520-5827
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2017-03-30en
rioxxterms.freetoread.startdate2018-03-30


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record