Selective Palladium(II)-Catalyzed Carbonylation of Methylene β-C-H Bonds in Aliphatic Amines.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Cabrera-Pardo, Jaime R
Trowbridge, Aaron
Nappi, Manuel
Ozaki, Kyohei
Gaunt, Matthew J https://orcid.org/0000-0002-7214-608X
Abstract
Palladium(II)-catalyzed C-H carbonylation reactions of methylene C-H bonds in secondary aliphatic amines lead to the formation of trans-disubstituted β-lactams in excellent yields and selectivities. The generality of the C-H carbonylation process is aided by the action of xantphos-based ligands and is important in securing good yields for the β-lactam products.
Description
Keywords
C−H activation, aliphatic amines, carbonylation, lactams, palladium catalysis
Journal Title
Angew Chem Int Ed Engl
Conference Name
Journal ISSN
1433-7851
1521-3773
1521-3773
Volume Title
56
Publisher
Wiley
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/I00548X/1)
European Research Council (259711)
European Commission (655856)
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (702462)
Engineering and Physical Sciences Research Council (EP/N031792/1)
European Research Council (259711)
European Commission (655856)
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (702462)
Engineering and Physical Sciences Research Council (EP/N031792/1)
EPSRC (EP/100548X/1), ERC (ERC-STG-259711), Royal Society (Wolfson Award), Marie Curie Foundation and Herchel Smith Foundation.