Identification of the viral molecules recognised by influenza specific human cytoxic T lymphocytes.
Published version
Peer-reviewed
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Repository DOI
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Authors
Smith, GL
Gotch, FM
McMichael, AJ
Moss, B
Abstract
Human cytotoxic T cells specific for influenza A virus were tested for recognition of each of the ten influenza A virus proteins expressed in target cells using recombinant vaccinia viruses. They recognized the matrix M1, polymerase PB2, and nucleoproteins of influenza virus in association with MHC class I antigens. These internal viral proteins were seen by CTL in conjunction with one or more of the available dependent HLA gene products. There was no detectable recognition of influenza virus surface glycoproteins in target cells.
Description
Keywords
Antigens, Viral, Cell Transformation, Viral, HLA Antigens, Herpesvirus 4, Human, Humans, Influenza A virus, Lymphocytes, Recombination, Genetic, T-Lymphocytes, Cytotoxic, Viral Proteins
Journal Title
Journal of Experimental Medicine
Conference Name
Journal ISSN
0022-1007
1540-9538
1540-9538
Volume Title
165
Publisher
Rockefeller University Press