Mitochondrial DNA depletion induces innate immune dysfunction rescued by interferon-γ
Accepted version
Peer-reviewed
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Abstract
Monocytes from sepsis patients have mitochondrial DNA (mtDNA) depletion and immune deactivation. Here we find that THP-1 cell immune responses are impaired by experimentally depleting mtDNA, through dysregulated immune signalling, and rescued by interferon-γ treatment.
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Keywords
DNA, Mitochondrial, DNA-Binding Proteins, Escherichia coli, Humans, Immunity, Innate, Interferon-gamma, Lipopolysaccharides, Mitochondrial Proteins, Phagocytosis, RNA, Small Interfering, Sepsis, THP-1 Cells, Transcription Factors
Journal Title
Journal of Allergy and Clinical Immunology
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Journal ISSN
0091-6749
1097-6825
1097-6825
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Publisher
Elsevier
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Sponsorship
Wellcome Trust (101876/Z/13/Z)