Mobile small RNAs and their role in regulating cytosine methylation of DNA
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Hardcastle, TJ
Lewsey, MG
Abstract
Small (s)RNAs of 21 to 24 nucleotides are associated with RNA silencing and methylation of DNA cytosine residues. All sizes can move from cell-to-cell and long distance in plants, directing RNA silencing in destination cells. Twenty-four nucleotide sRNAs are the predominant long-distance mobile species. Thousands move from shoot to root, where they target methylation of transposable elements both directly and indirectly. We derive several classes of interaction between small RNAs and methylation and use these to explore the mechanisms of methylation and gene expression that associate with mobile sRNA signaling.
Description
Keywords
Histone modifications, plant grafting, RNA-directed DNA methylation, small RNA, transcriptional gene silencing
Journal Title
RNA Biology
Conference Name
Journal ISSN
1547-6286
1555-8584
1555-8584
Volume Title
13
Publisher
Taylor & Francis
Publisher DOI
Sponsorship
European Research Council (340642)
This work was supported by European Research Council Advanced Investigator Grant ERC-2013-AdG 340642 – TRIBE. Work in MGL’s laboratory is supported by La Trobe University.