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Power analysis for random-effects meta-analysis

Published version
Peer-reviewed

Type

Article

Change log

Authors

Jackson, D 
Turner, R 

Abstract

One of the reasons for the popularity of meta-analysis is the notion that these analyses will possess more power to detect effects than individual studies. This is inevitably the case under a fixed-effect model. However, the inclusion of the between-study variance in the random-effects model, and the need to estimate this parameter, can have unfortunate implications for this power. We develop methods for assessing the power of random-effects meta-analyses, and the average power of the individual studies that contribute to meta-analyses, so that these powers can be compared. In addition to deriving new analytical results and methods, we apply our methods to 1991 meta-analyses taken from the Cochrane Database of Systematic Reviews to retrospectively calculate their powers. We find that, in practice, 5 or more studies are needed to reasonably consistently achieve powers from random-effects meta-analyses that are greater than the studies that contribute to them. Not only is statistical inference under the random-effects model challenging when there are very few studies but also less worthwhile in such cases. The assumption that meta-analysis will result in an increase in power is challenged by our findings.

Description

Keywords

cochrane, empirical evaluation, power calculations, random-effects meta-analysis, Bias, Databases, Factual, Humans, Meta-Analysis as Topic, Models, Statistical

Journal Title

Research Synthesis Methods

Conference Name

Journal ISSN

1759-2879
1759-2887

Volume Title

Publisher

Wiley
Sponsorship
MRC (unknown)