Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes
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Hockman, D., Burns, A., Schlosser, G., Gates, K., Jevans, B., Mongera, A., Fisher, S., et al. (2017). Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. Elife, 6 (e21231)https://doi.org/10.7554/eLife.21231
The evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes - carotid body glomus cells, and 'pulmonary neuroendocrine cells' (PNECs) - are obscure. Homology has been proposed between glomus cells, which are neural crest-derived, and the hypoxia-sensitive 'neuroepithelial cells' (NECs) of fish gills, whose embryonic origin is unknown. NECs have also been likened to PNECs, which differentiate in situ within lung airway epithelia. Using genetic lineage-tracing and neural crest-deficient mutants in zebrafish, and physical fate-mapping in frog and lamprey, we find that NECs are not neural crest-derived, but endoderm-derived, like PNECs, whose endodermal origin we confirm. We discover neural crest-derived catecholaminergic cells associated with zebrafish pharyngeal arch blood vessels, and propose a new model for amniote hypoxia-sensitive cell evolution: endoderm-derived NECs were retained as PNECs, while the carotid body evolved via the aggregation of neural crest-derived catecholaminergic (chromaffin) cells already associated with blood vessels in anamniote pharyngeal arches.
carotid body, chicken, developmental biology, endoderm, fate-mapping, mouse, neural crest, neuroepithelial cells, sea lamprey (Petromyzon marinus), stem cells, xenopus, zebrafish
This work was funded by the Wellcome Trust (Ph.D. Studentship 086804/Z/08/Z to DH; Senior Investigator Award 102889/Z/13/Z to AST), the NIDCR/NIH (R21-DE021509 to SF; R01-DE018477 to EWK), the NIDDK/NIH (1DP2DK098092 to PDSD), the NIH (R01-HL092217 to EWK), the Zebrafish Initiative of the Vanderbilt University Academic Venture Capital Fund (to EWK), the Vanderbilt International Scholar Program (to GU), the HFSP (Long-Term Fellowship to CM) and the Swiss National Science Foundation (Advanced Postdoctoral Fellowship and Professorship to CM). For further information, please visit the publisher's website.
Wellcome Trust (086804/Z/08/Z)
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External DOI: https://doi.org/10.7554/eLife.21231
This record's URL: https://www.repository.cam.ac.uk/handle/1810/266670