Bioprinting of three-dimensional culture models and organ-on-a-chip systems
Materials Research Society
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Huang, Y., Zhang, D., & Liu, Y. (2017). Bioprinting of three-dimensional culture models and organ-on-a-chip systems. MRS Bulletin, 42 (8), 593-598. https://doi.org/10.1557/mrs.2017.163
Multimaterial bioprinting technologies offer promising avenues to create mini-organ models with enhanced tissue heterogeneity and complexity. This article focuses on the application of three-dimensional bioprinting to fabricate organ-on-a-chip systems for in vitro drug testing and screening. We illustrate the capabilities and limitations of a bioprinting approach compared to microfabrication in constructing an organ-on-a-chip device. Further, we propose strategies in multimaterial integration for printing microphysiological tissue models. With these analyses, key challenges and future directions are highlighted.
D.Z. gratefully acknowledges support from the China Scholarship Council. Y.L. acknowledges the Schlumberger Foundation and Trinity College Cambridge. Y.Y.S.H. thanks EPSRC, the Royal Society London, and the Isaac Newton Trust for funding support.
External DOI: https://doi.org/10.1557/mrs.2017.163
This record's URL: https://www.repository.cam.ac.uk/handle/1810/267369