Multifunctional energy landscape for a DNA G-quadruplex: An evolved molecular switch
Journal of Chemical Physics
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Cragnolini, T., Chakraborty, D., Šponer, J., Derreumaux, P., Pasquali, S., & Wales, D. (2017). Multifunctional energy landscape for a DNA G-quadruplex: An evolved molecular switch. Journal of Chemical Physics, 147 (15. 152715)https://doi.org/10.1063/1.4997377
We explore the energy landscape for a four-fold telomere repeat, obtaining interconversion pathways between six experimentally characterised G-quadruplex topologies. The results reveal a multi-funnel system, with a variety of intermediate configurations and misfolded states. This organisation is identified with the intrinsically multi-functional nature of the system, suggesting a new paradigm for the classification of such biomolecules and clarifying issues regarding apparently conflicting experimental results.
Is supplemented by: https://www.repository.cam.ac.uk/handle/1810/254628
D.C. acknowledges the Cambridge Commonwealth, European and International Trusts for Ph.D. funding. T.C. acknowledges funding from EPSRC Grant No. EP/I001352/1. S.P. and P.D. acknowledge support from “DYNAMO” ANR- 11-LABX-0011 and PSL (Paris Sciences et Lettres). J.S. was supported by Czech Science Foundation Grant No. 16- 13721S. D.J.W. acknowledges funding from EPSRC Grant No. EP/N035003/1.
External DOI: https://doi.org/10.1063/1.4997377
This record's URL: https://www.repository.cam.ac.uk/handle/1810/267446