Continuous Preparation and Use of Dibromoformaldoxime as a Reactive Intermediate for the Synthesis of 3-Bromoisoxazolines
Lacerda Abreu, B
Organic Process Research and Development
American Chemical Society
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Battilocchio, C., Bosica, F., Rowe, S., Lacerda Abreu, B., Godineau, E., Lehmann, M., & Ley, S. (2017). Continuous Preparation and Use of Dibromoformaldoxime as a Reactive Intermediate for the Synthesis of 3-Bromoisoxazolines. Organic Process Research and Development https://doi.org/10.1021/acs.oprd.7b00229
We report the multistep continuous process for the preparation of dibromoformaldoxime (DBFO) as a precursor to generate 3-bromoisoxazolines. We also report process improvements that afford a productivity of over 620 mmol h−1 of DBFO.
Is supplemented by: https://doi.org/10.17863/CAM.12125
We would like to thank Syngenta Crop Protection AG (CB) and the EPSRC (SVL, grant nos. EP/K009494/1, EP/ M004120/1, and EP/K039520/1) for financial support.
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
External DOI: https://doi.org/10.1021/acs.oprd.7b00229
This record's URL: https://www.repository.cam.ac.uk/handle/1810/267482