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Continuous Preparation and Use of Dibromoformaldoxime as a Reactive Intermediate for the Synthesis of 3-Bromoisoxazolines

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Battilocchio, Claudio  ORCID logo  https://orcid.org/0000-0002-4601-8527
Bosica, F 
Rowe, SM 
Lacerda Abreu, B 
Godineau, E 

Abstract

We report the multistep continuous process for the preparation of dibromoformaldoxime (DBFO) as a precursor to generate 3-bromoisoxazolines. We also report process improvements that afford a productivity of over 620 mmol h−1 of DBFO.

Description

Keywords

3405 Organic Chemistry, 34 Chemical Sciences

Journal Title

Organic Process Research and Development

Conference Name

Journal ISSN

1083-6160
1520-586X

Volume Title

Publisher

American Chemical Society
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
We would like to thank Syngenta Crop Protection AG (CB) and the EPSRC (SVL, grant nos. EP/K009494/1, EP/ M004120/1, and EP/K039520/1) for financial support.
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