Continuous Preparation and Use of Dibromoformaldoxime as a Reactive Intermediate for the Synthesis of 3-Bromoisoxazolines

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Authors
  Battilocchio, Claudio
Bosica, F
  Rowe, Sam
Lacerda Abreu, B
Godineau, E
Lehmann, M
  Ley, Steven
Publication Date
2017-10
Journal Title
Organic Process Research and Development
ISSN
1083-6160
Publisher
American Chemical Society
Type
Article
This Version
AM
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Citation
Battilocchio, C., Bosica, F., Rowe, S., Lacerda Abreu, B., Godineau, E., Lehmann, M., & Ley, S. (2017). Continuous Preparation and Use of Dibromoformaldoxime as a Reactive Intermediate for the Synthesis of 3-Bromoisoxazolines. Organic Process Research and Development https://doi.org/10.1021/acs.oprd.7b00229
Abstract
We report the multistep continuous process for the preparation of dibromoformaldoxime (DBFO) as a precursor to generate 3-bromoisoxazolines. We also report process improvements that afford a productivity of over 620 mmol h−1 of DBFO.
Relationships
Is supplemented by: https://doi.org/10.17863/CAM.12125
Sponsorship
We would like to thank Syngenta Crop Protection AG (CB) and the EPSRC (SVL, grant nos. EP/K009494/1, EP/ M004120/1, and EP/K039520/1) for financial support.
Funder references
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Identifiers
External DOI: https://doi.org/10.1021/acs.oprd.7b00229
This record's URL: https://www.repository.cam.ac.uk/handle/1810/267482
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Licence:
http://www.rioxx.net/licenses/all-rights-reserved
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