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TCTP in development and cancer.


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Authors

Koziol, Magdalena J 
Gurdon, John B 

Abstract

The translationally controlled tumor protein (TCTP) is highly conserved among animal species. It is widely expressed in many different tissues. It is involved in regulating many fundamental processes, such as cell proliferation and growth, apoptosis, pluripotency, and the cell cycle. Hence, it is not surprising that it is essential for normal development and, if misregulated, can lead to cancer. Provided herein is an overview of the diverse functions of TCTP, with a focus on development. Furthermore, we discuss possible ways by which TCTP misregulation or mutation could result in cancer.

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Keywords

0601 Biochemistry and Cell Biology, 1112 Oncology and Carcinogenesis, Biomedical, Basic Science, Cancer, Rare Diseases, Cancer

Journal Title

Biochem Res Int

Conference Name

Journal ISSN

2090-2247
2090-2255

Volume Title

Publisher

Hindawi Limited
Sponsorship
Medical Research Council (G1001690)