TCTP in Development and Cancer
Koziol, Magdalena J.
Gurdon, John B.
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Koziol, M. J., & Gurdon, J. B. (2012). TCTP in Development and Cancer. https://doi.org/10.1155/2012/105203
The translationally controlled tumor protein (TCTP) is highly conserved among animal species. It is widely expressed in many different tissues. It is involved in regulating many fundamental processes, such as cell proliferation and growth, apoptosis, pluripotency, and the cell cycle. Hence, it is not surprising that it is essential for normal development and, if misregulated, can lead to cancer. Provided herein is an overview of the diverse functions of TCTP, with a focus on development. Furthermore, we discuss possible ways by which TCTP misregulation or mutation could result in cancer.
External DOI: https://doi.org/10.1155/2012/105203
This record's URL: https://www.repository.cam.ac.uk/handle/1810/267593
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Rights Holder: Copyright © 2012 Magdalena J. Koziol and John B. Gurdon. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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