Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications.
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Abstract
Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriving clinical implications.
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3101 Biochemistry and Cell Biology, 31 Biological Sciences, Genetics, Regenerative Medicine, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human, Human Genome, Stem Cell Research - Nonembryonic - Human, Aging, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Inflammatory and immune system
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Stem Cells Int
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1687-966X
1687-9678
1687-9678
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Wiley
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Except where otherwised noted, this item's license is described as All Rights Reserved
Sponsorship
Medical Research Council (MR/K024043/1)
European Commission (282510)
British Heart Foundation (None)
European Commission (282510)
British Heart Foundation (None)
Fizzah Aziz Choudry is recipient of an MRC clinical fellowship (MR/K024043/1). Mattia Frontini is supported by the BHF Cambridge Centre of Excellence [RE/13/6/30180] and EU-FP7 project BLUEPRINT (282510).