Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications.
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Authors
Choudry, Fizzah Aziz
Abstract
Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriving clinical implications.
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Keywords
0604 Genetics, Biomedical, Basic Science, Aging, Human Genome, Genetics, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human, Regenerative Medicine, Blood, Generic Health Relevance, Inflammatory and Immune System, 1.1 Normal biological development and functioning
Journal Title
Stem Cells Int
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Journal ISSN
1687-966X
1687-9678
1687-9678
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Publisher
Hindawi Limited
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Sponsorship
Medical Research Council (MR/K024043/1)
European Commission (282510)
European Commission (282510)
Fizzah Aziz Choudry is recipient of an MRC clinical fellowship (MR/K024043/1). Mattia Frontini is supported by the BHF Cambridge Centre of Excellence [RE/13/6/30180] and EU-FP7 project BLUEPRINT (282510).