Host control of human papillomavirus infection and disease
Best Practice & Research Clinical Obstetrics & Gynaecology
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Doorbar, J. (2017). Host control of human papillomavirus infection and disease. Best Practice & Research Clinical Obstetrics & Gynaecology https://doi.org/10.1016/j.bpobgyn.2017.08.001
Most human papillomaviruses cause inapparent infections, subtly affecting epithelial homeostasis, to ensure genome persistence in the epithelial basal layer. As with conspicuous papillomas, these self-limiting lesions shed viral particles to ensure population level maintenance and depend on a balance between viral gene expression, immune cell stimulation and immune surveillance for persistence. The complex immune evasion strategies, characteristic of high-risk HPV types, also allow the deregulated viral gene expression that underlies neoplasia. Neoplasia occurs at particular epithelial sites where vulnerable cells such as the reserve or cuboidal cells of the cervical transformation zone are found. Beta papillomavirus infection can also predispose an individual with immune deficiencies to the development of cancers. The host control of HPV infections thus involves local interactions between keratinocytes and the adaptive immune response. Effective immune detection and surveillance limits overt disease, leading to HPV persistence as productive microlesions or in a true latent state.
papillomavirus, epithelial homeostasis, wart, CIN, HPV
Support by the Medical Research Council (programme grant U117584278) has allowed the formulation of many of the ideas outlined in this review.
External DOI: https://doi.org/10.1016/j.bpobgyn.2017.08.001
This record's URL: https://www.repository.cam.ac.uk/handle/1810/267673