Cancer Immunotherapy Trials Underutilize Immune Response Monitoring.
Raby, Sophie EM
Fearon, Douglas T
AlphaMed Press Inc
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Connell, C., Raby, S. E., Beh, I., Flint, T., Williams, E., Fearon, D. T., Jodrell, D., & et al. (2018). Cancer Immunotherapy Trials Underutilize Immune Response Monitoring.. The oncologist, 23 (1), 116-117. https://doi.org/10.1634/theoncologist.2017-0226
Immune‐related radiological and biomarker monitoring in cancer immunotherapy trials permits interrogation of efficacy and reasons for therapeutic failure. We report the results from a cross‐sectional analysis of response monitoring in 685 T‐cell checkpoint‐targeted cancer immunotherapy trials in solid malignancies, as registered on the U.S. National Institutes of Health trial registry by October 2016. Immune‐related radiological response criteria were registered for only 25% of clinical trials. Only 38% of trials registered an exploratory immunological biomarker, and registration of immunological biomarkers has decreased over the last 15 years. We suggest that increasing the utilization of immune‐related response monitoring across cancer immunotherapy trials will improve analysis of outcomes and facilitate translational efforts to extend the benefit of immunotherapy to a greater proportion of patients with cancer.
Humans, Neoplasms, Monitoring, Immunologic, Prognosis, Immunotherapy, Cross-Sectional Studies, Immunity, Cellular, Antineoplastic Agents, Immunological
This work was supported by the Wellcome Trust Translational Medicine and Therapeutics Programme [RJAG/076 to T.J], by Cancer Research UK [C42738/A24868 to TJ], and the Cambridge Translational Medicine and Therapeutics Academic Clinical Fellowship Programme (C.M.C).
External DOI: https://doi.org/10.1634/theoncologist.2017-0226
This record's URL: https://www.repository.cam.ac.uk/handle/1810/267865