Movassagh et al. (May 25 issue) report an association between a synonymous variant (rs165631) in COMT and a reduced risk of cancer among female carriers of the mutation BRCA1 or BRCA2. The result was based on an analysis involving 25 patients with breast cancer who had germline BRCA1/2 alterations in the Cancer Genome Atlas and 15 presumably cancer-free women with BRCA1/2 nonsense and frameshift alterations in the Exome Sequencing Project of the National Heart, Lung, and Blood Institute (NHLBI). Given the potential for misinterpretation of the results, we feel obliged to correct the impression that rs165631 protects carriers of the BRCA1 or BRCA2 mutation from cancer.