Recruitment of endogenous CNS stem cells for regeneration in demyelinating disease.
Accepted version
Peer-reviewed
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Repository DOI
Type
Article
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Authors
Murphy, Natalia A
Franklin, Robin JM
Abstract
Demyelinating diseases, such as multiple sclerosis (MS), are responsible for a significant portion of the neurological disability burden worldwide, especially in young adults. Demyelination can be followed by a spontaneous regenerative process called remyelination, in which new myelin sheaths are restored to denuded axons. However, in chronic demyelinating disease such as MS, this process becomes progressively less efficient. This chapter reviews the biology of remyelination and the rationale and strategies by which it can be enhanced therapeutically in acquired demyelinating disease.
Description
Keywords
Adult stem cells, Demyelination, Multiple sclerosis, Myelin, OPC, Oligodendrocyte, Remyelination, Demyelinating Diseases, Humans, Multiple Sclerosis, Myelin Sheath, Nerve Regeneration, Remyelination, Stem Cells
Journal Title
Prog Brain Res
Conference Name
Journal ISSN
0079-6123
1875-7855
1875-7855
Volume Title
231
Publisher
Elsevier
Publisher DOI
Sponsorship
Medical Research Council (MC_PC_12009)