Effect of hyoscine butylbromide on prostate multiparametric MRI anatomical and functional image quality.
W. B. Saunders Co., Ltd.
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Slough, R., Caglic, I., Hansen, N., Patterson, A., & Barrett, T. (2018). Effect of hyoscine butylbromide on prostate multiparametric MRI anatomical and functional image quality.. Clinical radiology, 73 (2), 216.e9-216.e14. https://doi.org/10.1016/j.crad.2017.07.013
Abstract Purpose: To evaluate the effect of the spasmolytic agent hyoscine butylbromide (HBB) on the quality of anatomical and functional imaging of the prostate. Materials and Methods: 173 patients were included in this retrospective study. 87 patients received intravenous HBB prior to scanning (HBB group) and 86 patients did not (non-HBB group). Multiparametric (mp) 3T-MRI was performed using a 32-channel body coil. Two radiologists independently evaluated image quality of T2WI, diffusion-weighted imaging (DWI) and ADC maps, using a 5-point Likert scale. DWI was further assessed for distortion and artefact (4-point Likert scale), and T2WI for the presence of motion artefact or blurring. DCE image quality was assessed by recording the number of corrupt contrast curve data points. Results: T2W image quality in the HBB group was significantly higher than in the non-HBB group (3.63 ± 1.11 versus 2.84 ± 0.899); p = <0.001. The HBB group also showed significantly less T2W motion and T2W blur than the non-HBB group (23.0% and 51.7% versus 53.5% and 83.7%, respectively; p = <0.001). However, there was no significant improvement in DWI or ADC image quality, or DWI degree of distortion or artefact. There was a trend towards a lower number of corrupted data points from the contrast curve (2.47 ± 2.44 versus 3.68 ± 2.64), but this did not reach significance (p = 0.052). Conclusion: Administration of HBB significantly improves the image quality of T2-weighted images. These results provide evidence for the use of HBB in routine patient preparation prior to prostate mpMRI.
Prostate, Humans, Organometallic Compounds, Butylscopolammonium Bromide, Muscarinic Antagonists, Contrast Media, Magnetic Resonance Imaging, Image Enhancement, Artifacts, Retrospective Studies, Adult, Aged, Middle Aged, Male
Cancer Research UK, National Institute of Health Research Cambridge Biomedical Research Centre, Cancer Research UK and the Engineering and Physical Sciences Research Council Imaging Centre in Cambridge and Manchester and the Cambridge Experimental Cancer Medicine Centre.
External DOI: https://doi.org/10.1016/j.crad.2017.07.013
This record's URL: https://www.repository.cam.ac.uk/handle/1810/269900