Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.

Long, Lu; Ormiston, Mark; Yang, XuDong; Southwood, Mark; Graf, Stefan; Machado, Rajiv D; Mueller, Matthias; Kinzel, Bernd; Yung, Lai Ming; Wilkinson, Janine; Moore, Stephen; Drake, Kylie M; Aldred, Micheala A; Yu, Paul B; Upton, Paul; Morrell, Nicholas

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Authors

Long, Lu

Ormiston, Mark

Yang, XuDong

Southwood, Mark

Graf, Stefan

Machado, Rajiv D

Mueller, Matthias

Publication Date

2015-07

Journal Title

Nature medicine

ISSN

1078-8956

Volume

Issue

Pages

777-785

Language

eng

Type

Article

This Version

Physical Medium

Print-Electronic

Metadata

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Citation

Long, L., Ormiston, M., Yang, X., Southwood, M., Graf, S., Machado, R. D., Mueller, M., et al. (2015). Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.. Nature medicine, 21 (7), 777-785. https://doi.org/10.1038/nm.3877

Keywords

Pulmonary Artery, Heart Ventricles, Endothelial Cells, Animals, Mice, Inbred C57BL, Humans, Rats, Rats, Sprague-Dawley, Hypertension, Pulmonary, Monocrotaline, JNK Mitogen-Activated Protein Kinases, Immunoblotting, Densitometry, Gene Expression Profiling, Apoptosis, Cell Membrane Permeability, Transcription, Genetic, Phosphorylation, Aging, Systole, Male, Bone Morphogenetic Protein Receptors, Type II, Growth Differentiation Factor 2, Gene Knock-In Techniques

Sponsorship

British Heart Foundation (PG/10/35/28339)

British Heart Foundation (CH/09/001/25945)

British Heart Foundation (PG/11/10/28724)

British Heart Foundation (RG/13/4/30107)

MRC (MR/K020919/1)

MRC (G1000847)

British Heart Foundation (PG/12/54/29734)

MRC (G0800784)

Identifiers

External DOI: https://doi.org/10.1038/nm.3877

This record's URL: https://www.repository.cam.ac.uk/handle/1810/271025

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