From haematopoietic stem cells to complex differentiation landscapes
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Publication Date
2018-01-25Journal Title
Nature
ISSN
0028-0836
Publisher
Springer Nature
Volume
553
Pages
418-426
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Laurenti, E., & Gottgens, B. (2018). From haematopoietic stem cells to complex differentiation landscapes. Nature, 553 418-426. https://doi.org/10.1038/nature25022
Abstract
The development of mature blood cells from haematopoietic stem cells has long served as a model for stem-cell research, with the haematopoietic differentiation tree being widely used as a model for the maintenance of hierarchically organized tissues. Recent results and new technologies have challenged the demarcations between stem and progenitor cell populations, the timing of cell-fate choices and the contribution of stem and multipotent progenitor cells to the maintenance of steady-state blood production. These evolving views of haematopoiesis have broad implications for our understanding of the functions of adult stem cells, as well as the development of new therapies for malignant and non-malignant haematopoietic diseases.
Sponsorship
E.L. is supported by a Sir Henry Dale fellowship from the Wellcome Trust (WT)/Royal Society. Research in the Laurenti and Gottgens laboratories is supported by the WT, CRUK, Bloodwise, MRC, BBSRC, NIH-NIDDK, and core support grants by the WT and MRC to the Wellcome-MRC Cambridge Stem Cell Institute.
Funder references
BBSRC (BB/P002293/1)
MRC (G0900951)
Cancer Research UK (A8043)
Isaac Newton Trust (MINUTE 646(M))
Leukaemia & Lymphoma Research (7060)
Leukaemia & Lymphoma Research (8061)
MEDICAL RESEARCH COUNCIL (MR/M008975/1)
MRC (MC_PC_12009)
WELLCOME TRUST (107630/Z/15/Z)
National Institutes of Health (NIH) (via Pennsylvania State University) (R24DK106766)
Cancer Research UK (21762)
Leukaemia & Lymphoma Research (6072)
Leukaemia & Lymphoma Research (238)
Leukaemia & Lymphoma Research (12029)
Identifiers
External DOI: https://doi.org/10.1038/nature25022
This record's URL: https://www.repository.cam.ac.uk/handle/1810/271359
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