Do gadolinium-based contrast agents alter 23Na T1 relaxivity in glioma?
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Peer-reviewed
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Riemer, Frank https://orcid.org/0000-0002-3805-5221
McLean, MA
Zaccagna, Fulvio https://orcid.org/0000-0001-6838-9532
Grist, JT
Schulte, Rolf
Abstract
Incomplete fluid suppression on fluid-attenuated inversion-recovery 23Na-MRI (IR-23Na-MRI) was observed in three patients undergoing IR-23Na-MRI after gadolinium contrast injection, as part of a brain tumour imaging study. To evaluate this, 23Na-MRI T1 maps were acquired before and after injection of a gadolinium-based contrast agent on a grade IV glioma (GBM) patient, which showed a statistically significant change of 23Na-MRI T1 within the peritumoral oedema (p=0.0095). Gadolinium contrast-enhanced 23Na-MRI could potentially add further applications for sodium imaging and probe tumour tissue structure in new ways to investigate proliferation and treatment response.
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The International Society for Magnetic Resonance in Medicine (ISMRM) 25th Annual Meeting & Exhibition
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International Society for Magnetic Resonance in Medicine
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Cancer Research Uk (None)
MRC (1508766)
MRC (1508766)