Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity.
BioEssays : news and reviews in molecular, cellular and developmental biology
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Ecker, S., Pancaldi, V., Valencia, A., Beck, S., & Paul, D. (2018). Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity.. BioEssays : news and reviews in molecular, cellular and developmental biology, 40 (2)https://doi.org/10.1002/bies.201700148
Epigenetic and transcriptional variability contribute to the vast diversity of cellular and organismal phenotypes and are key in human health and disease. In this review, we describe different types, sources and determinants of epigenetic and transcriptional variability, enabling cells and organisms to adapt and evolve to a changing environment. We highlight the latest research and hypotheses on how chromatin structure and the epigenome influence gene expression variability. Further, we provide an overview of challenges in the analysis of biological variability. An improved understanding of the molecular mechanisms underlying epigenetic and transcriptional variability, at both the intra- and interindividual level, provides great opportunity for disease prevention, better therapeutic approaches and personalized medicine.
Chromatin, Humans, Adaptation, Physiological, Transcription, Genetic, Epigenesis, Genetic, Genetic Variation, Precision Medicine, Biological Variation, Population, Biological Variation, Individual
British Heart Foundation (RG/08/014/24067)
British Heart Foundation (RG/13/13/30194)
European Commission Horizon 2020 (H2020) Societal Challenges (733161)
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External DOI: https://doi.org/10.1002/bies.201700148
This record's URL: https://www.repository.cam.ac.uk/handle/1810/271763
Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/
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