Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity.
Publication Date
2018-02Journal Title
Bioessays
ISSN
0265-9247
Publisher
Wiley
Volume
40
Issue
2
Language
eng
Type
Article
This Version
VoR
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Ecker, S., Pancaldi, V., Valencia, A., Beck, S., & Paul, D. (2018). Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity.. Bioessays, 40 (2) https://doi.org/10.1002/bies.201700148
Abstract
Epigenetic and transcriptional variability contribute to the vast diversity of cellular and organismal phenotypes and are key in human health and disease. In this review, we describe different types, sources, and determinants of epigenetic and transcriptional variability, enabling cells and organisms to adapt and evolve to a changing environment. We highlight the latest research and hypotheses on how chromatin structure and the epigenome influence gene expression variability. Further, we provide an overview of challenges in the analysis of biological variability. An improved understanding of the molecular mechanisms underlying epigenetic and transcriptional variability, at both the intra- and inter-individual level, provides great opportunity for disease prevention, better therapeutic approaches, and personalized medicine.
Keywords
Chromatin, Humans, Adaptation, Physiological, Transcription, Genetic, Epigenesis, Genetic, Genetic Variation, Precision Medicine, Biological Variation, Population, Biological Variation, Individual
Sponsorship
Medical Research Council (MR/L003120/1)
British Heart Foundation (None)
British Heart Foundation (None)
European Commission Horizon 2020 (H2020) Societal Challenges (733161)
Embargo Lift Date
2100-01-01
Identifiers
External DOI: https://doi.org/10.1002/bies.201700148
This record's URL: https://www.repository.cam.ac.uk/handle/1810/271763
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