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Recent Submissions

  • How TCR signal strength controls CTL polarisation for target killing 

    Frazer, Gordon Lee (2018-09-30)
    Cytotoxic T lymphocytes (CTL) are major effector cells in the adaptive immune response against intracellular pathogens and cancers, killing targets with high precision. Precision is achieved through the specificity of the ...
  • Characterisation of LITAF, a protein associated with Charcot-Marie-Tooth disease type 1C 

    Ho, Hon Kwan (2018-07-01)
    Charcot-Marie-Tooth disease (CMT) is the commonest inherited neuromuscular disorder, which affects the peripheral nervous system leading to nerve degeneration. CMT is categorised into two forms, ‘axonal’ and ‘demyelinating’, ...
  • Tackling Mycobacterium abscessus infection in Cystic Fibrosis 

    Rodriguez Rincon, Daniela (2018-05-19)
    Mycobacterium abscessus is an emerging pathogen with infections increasing worldwide, especially among Cystic Fibrosis (CF) patients. During my PhD, I studied key aspects of the biology of M. abscessus spp.; particularly, ...
  • Decoding Lysine-11 Signals in Ubiquitination 

    Grice, Guinevere (2018-04-04)
    The diverse outcomes of ubiquitination primarily relate to the flexibility of ubiquitin in forming homo- or heterotypic chains on each of its seven lysine residues which in turn stimulate distinct downstream signaling ...

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