The neuroanatomical and neurochemical basis of apathy and impulsivity in frontotemporal lobar degeneration.
Current opinion in behavioral sciences
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Passamonti, L., Lansdall, C., & Rowe, J. (2018). The neuroanatomical and neurochemical basis of apathy and impulsivity in frontotemporal lobar degeneration.. Current opinion in behavioral sciences, 22 14-20. https://doi.org/10.1016/j.cobeha.2017.12.015
Apathy and impulsivity are common and often coexistent consequences of frontotemporal lobar degeneration (FTLD). They increase patient morbidity and carer distress, but remain under-estimated and poorly treated. Recent trans-diagnostic approaches that span the spectrum of clinical presentations of FTLD and parkinsonism, indicate that apathy and impulsivity can be fractionated into multiple neuroanatomical and pharmacological systems. These include ventral/dorsal fronto-striatal circuits for reward-sensitivity, response-inhibition, and decision-making; moderated by noradrenaline, dopamine, and serotonin. Improved assessment tools, formal models of cognition and behavior, combined with brain imaging and psycho-pharmacology, are creating new therapeutic targets and establishing principles for stratification in future clinical trials.
WELLCOME TRUST (103838/Z/14/Z)
James S McDonnell Foundation (220020289)
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External DOI: https://doi.org/10.1016/j.cobeha.2017.12.015
This record's URL: https://www.repository.cam.ac.uk/handle/1810/273798
Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/
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