Adiaspiromycosis in a wild European rabbit, and a review of the literature.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
American Association of Veterinary Laboratory Diagnosticians
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Hughes, K., & Borman, A. M. (2018). Adiaspiromycosis in a wild European rabbit, and a review of the literature.. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 30 (4), 614-618. https://doi.org/10.1177/1040638718772631
Adiaspiromycosis is a mycotic infection caused by thermally dimorphic fungi, until recently classified as Emmonsia parva and E. crescens (formerly Chrysosporium spp.). We document the pathological findings in a severe case of adiaspiromycosis, with lymph node involvement, in a wild European rabbit (Oryctolagus cuniculus). The rabbit exhibited granulomatous pneumonia with tracheobronchial lymph node enlargement. Histopathologically, the lung was expanded by myriad, densely cellular, heterophilic and granulomatous foci, surrounding bi- to trilaminar adiaspores. Adiaspore density was considered to be similar in all lung lobes. In the left caudal lung lobe, 80 adiaspores were counted in a 50 mm2 area using digital image analysis. The mean and median adiaspore diameters were 240 ± 52 μm and 255 μm respectively. Tracheobronchial lymph nodes exhibited moderate numbers of similar adiaspores. PCR amplification of DNA extracted from micro-dissected adiaspores failed to identify Emmonsia spp.-specific DNA. These data suggest that adiaspiromycosis may result in severe granulomatous pneumonia in wild European rabbits. Although confirmation of the etiologic agent by PCR using DNA extracted from formalin-fixed tissue is not always successful, digital image analysis can be used to aid accurate assessment of adiaspore density and morphology.
Animals, Rabbits, Chrysosporium, Mycoses, Lung Diseases, Fungal
External DOI: https://doi.org/10.1177/1040638718772631
This record's URL: https://www.repository.cam.ac.uk/handle/1810/274108