New models to study vascular mural cell embryonic origin: implications in vascular diseases.
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Sinha, S., & Santoro, M. M. (2018). New models to study vascular mural cell embryonic origin: implications in vascular diseases.. Cardiovascular research, 114 (4), 481-491. https://doi.org/10.1093/cvr/cvy005
A key question in vascular biology is how the diversity of origin of vascular mural cells, namely smooth muscle cells and pericytes influences vessel properties, in particular the regional propensity to vascular diseases. This review therefore first describes the role and regulation of mural cells during vascular formation, with a focus on embryonic origin. We then consider the evidence that connects heterogeneities in smooth muscle cell and pericyte origins with disease. Since this idea has major implications for understanding and modelling human disease, then there is a pressing need for new model systems to investigate mural cell development and the consequences of heterogeneity. Recent advances arising from in vitro strategies for deriving mural cells from human pluripotent stem cells as well as from the zebrafish model will be discussed and the medical relevance of these discoveries will be highlighted.
Myocytes, Smooth Muscle, Animals, Zebrafish, Humans, Vascular Diseases, Cell Communication, Signal Transduction, Gene Expression Regulation, Developmental, Cell Lineage, Neovascularization, Physiologic, Phenotype, Embryonic Stem Cells, Induced Pluripotent Stem Cells
British Heart Foundation (FS/13/29/30024)
British Heart Foundation (FS/13/65/30441)
External DOI: https://doi.org/10.1093/cvr/cvy005
This record's URL: https://www.repository.cam.ac.uk/handle/1810/274139