Nuclear transplantation, the conservation of the genome, and prospects for cell replacement.
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Gurdon, J. (2017). Nuclear transplantation, the conservation of the genome, and prospects for cell replacement.. FEBS Journal, 284 (2), 211-217. https://doi.org/10.1111/febs.13988
Initial nuclear transplantation experiments in Xenopus eggs provided the first evidence for the conservation of the genome after cellular differentiation. This Discovery-in-Context Review recounts the early experiments that led to successful nuclear transfer in amphibians and the establishment of totipotency of a differentiated cell and shows how these discoveries paved the way for similar cloning experiments in other organisms.
Briggs and King, Dolly the sheep, Michael Fischberg, Xenopus eggs, cell replacement therapy, enucleation of GV, intestinal epithelium, nuclear transplantation, nucleolus organizer, somatic cell nucleus, Animals, Cattle, Cell Differentiation, Cell Nucleus, Cloning, Organism, Genome, Genomic Instability, History, 20th Century, History, 21st Century, Mice, Nuclear Transfer Techniques, Oocytes, Sheep, Swine, Xenopus laevis
External DOI: https://doi.org/10.1111/febs.13988
This record's URL: https://www.repository.cam.ac.uk/handle/1810/274196