Regulation of neuronal development and function by ROS.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Oswald, Matthew CW
Garnham, Nathan
Sweeney, Sean T
Landgraf, Matthias https://orcid.org/0000-0001-5142-1997
Abstract
Reactive oxygen species (ROS) have long been studied as destructive agents in the context of nervous system ageing, disease and degeneration. Their roles as signalling molecules under normal physiological conditions is less well understood. Recent studies have provided ample evidence of ROS-regulating neuronal development and function, from the establishment of neuronal polarity to growth cone pathfinding; from the regulation of connectivity and synaptic transmission to the tuning of neuronal networks. Appreciation of the varied processes that are subject to regulation by ROS might help us understand how changes in ROS metabolism and buffering could progressively impact on neuronal networks with age and disease.
Description
Keywords
NADPH oxidase, axon, cytoskeleton, dendrite, nervous system, neuronal polarity, pathfinding, plasticity, reactive oxygen species, synapse, Aging, Animals, Growth Cones, Humans, Nerve Net, Neurodegenerative Diseases, Neurogenesis, Reactive Oxygen Species, Synaptic Transmission
Journal Title
FEBS Lett
Conference Name
Journal ISSN
0014-5793
1873-3468
1873-3468
Volume Title
592
Publisher
Wiley
Publisher DOI
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/M002934/1)
Biotechnology and Biological Sciences Research Council (BB/I01179X/1)
Biotechnology and Biological Sciences Research Council (BB/I01179X/1)