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Regulation of neuronal development and function by ROS.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Oswald, Matthew CW 
Garnham, Nathan 
Sweeney, Sean T 

Abstract

Reactive oxygen species (ROS) have long been studied as destructive agents in the context of nervous system ageing, disease and degeneration. Their roles as signalling molecules under normal physiological conditions is less well understood. Recent studies have provided ample evidence of ROS-regulating neuronal development and function, from the establishment of neuronal polarity to growth cone pathfinding; from the regulation of connectivity and synaptic transmission to the tuning of neuronal networks. Appreciation of the varied processes that are subject to regulation by ROS might help us understand how changes in ROS metabolism and buffering could progressively impact on neuronal networks with age and disease.

Description

Keywords

NADPH oxidase, axon, cytoskeleton, dendrite, nervous system, neuronal polarity, pathfinding, plasticity, reactive oxygen species, synapse, Aging, Animals, Growth Cones, Humans, Nerve Net, Neurodegenerative Diseases, Neurogenesis, Reactive Oxygen Species, Synaptic Transmission

Journal Title

FEBS Lett

Conference Name

Journal ISSN

0014-5793
1873-3468

Volume Title

592

Publisher

Wiley
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/M002934/1)
Biotechnology and Biological Sciences Research Council (BB/I01179X/1)