Broad Chromatin Domains: An Important Facet of Genome Regulation.
BioEssays : news and reviews in molecular, cellular and developmental biology
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Carelli, F. N., Sharma, G., & Ahringer, J. (2017). Broad Chromatin Domains: An Important Facet of Genome Regulation.. BioEssays : news and reviews in molecular, cellular and developmental biology, 39 (12)https://doi.org/10.1002/bies.201700124
Chromatin composition differs across the genome, with distinct compositions characterizing regions associated with different properties and functions. Whereas many histone modifications show local enrichment over genes or regulatory elements, marking can also span large genomic intervals defining broad chromatin domains. Here we highlight structural and functional features of chromatin domains marked by histone modifications, with a particular emphasis on the potential roles of H3K27 methylation domains in the organization and regulation of genome activity in metazoans.
Chromatin, Animals, Mice, Drosophila melanogaster, Caenorhabditis elegans, Lysine, Histones, Chromatin Immunoprecipitation, Chromatin Assembly and Disassembly, Epigenesis, Genetic, Protein Processing, Post-Translational, Methylation, Genome, Promoter Regions, Genetic
Wellcome Trust (101863/Z/13/Z)
Royal Society (NF160767)
Embargo Lift Date
External DOI: https://doi.org/10.1002/bies.201700124
This record's URL: https://www.repository.cam.ac.uk/handle/1810/274956
Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/
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