Mitochondria and Hypoxia: Metabolic Crosstalk in Cell-Fate Decisions.
Trends in endocrinology and metabolism: TEM
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Bargiela, D., Burr, S., & Chinnery, P. (2018). Mitochondria and Hypoxia: Metabolic Crosstalk in Cell-Fate Decisions.. Trends in endocrinology and metabolism: TEM, 29 (4), 249-259. https://doi.org/10.1016/j.tem.2018.02.002
Alterations in mitochondrial metabolism influence cell differentiation and growth. This process is regulated by the activity of 2-oxoglutarate-dependent dioxygenases (2OGDDs) - a diverse superfamily of oxygen-consuming enzymes - through modulation of the epigenetic landscape and transcriptional responses. Recent reports have described the role of mitochondrial metabolites in directing 2OGDD-driven cell fate switches in stem cells, immune cell and cancer cells. An understanding of the metabolic mechanisms underlying 2OGDD autoregulation is required for therapeutic targeting of this system. We propose a model dependent on oxygen and metabolite availability and discuss how this integrates 2OGDD metabolic signaling, the hypoxic transcriptional response and fate-determining epigenetic changes.
Mitochondria, Animals, Humans, Cell Differentiation, Homeostasis, Hypoxia
WELLCOME TRUST (101876/Z/13/Z)
External DOI: https://doi.org/10.1016/j.tem.2018.02.002
This record's URL: https://www.repository.cam.ac.uk/handle/1810/275001