The combination of cardiorespiratory fitness and muscle strength, and mortality risk.
Authors
Publication Date
2018-10Journal Title
European journal of epidemiology
ISSN
0393-2990
Publisher
Springer Nature
Volume
33
Issue
10
Pages
953-964
Language
eng
Type
Article
This Version
VoR
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Kim, Y., White, T., Wijndaele, K., Westgate, K., Sharp, S., Helge, J. W., Wareham, N., & et al. (2018). The combination of cardiorespiratory fitness and muscle strength, and mortality risk.. European journal of epidemiology, 33 (10), 953-964. https://doi.org/10.1007/s10654-018-0384-x
Abstract
Abstract
Little is known about the combined associations of cardiorespiratory fitness (CRF) and hand grip strength (GS) with mortality in general adult populations. The purpose of this study was to compare the relative risk of mortality for CRF, GS, and their combination. In UK Biobank, a prospective cohort of >0.5 million adults aged 40-69yrs, CRF was measured through submaximal bike tests; GS was measured using a hand-dynamometer. This analysis is based on data from 70,913 men and women (832 all-cause, 177 cardiovascular and 503 cancer deaths over 5.7-year follow-up) who provided valid CRF and GS data, and with no history of heart attack/stroke/cancer at baseline. Compared with the lowest CRF category, the hazard ratio (HR) for all-cause mortality was 0.76 (95% confidence interval [CI]: 0.64-0.89) and 0.65 (95% CI: 0.55-0.78) for the middle and highest CRF categories, respectively, after adjustment for confounders and GS. The highest GS category had an HR of 0.79 (95% CI: 0.66-0.95) for all-cause mortality compared with the lowest, after adjustment for confounders and CRF. Similar results were found for cardiovascular and cancer mortality. The HRs for the combination of highest CRF and GS were 0.53 (95% CI: 0.39-46 0.72) for all-cause mortality and 0.31 (95% CI: 0.14-0.67) for cardiovascular mortality, compared with the reference category of lowest CRF and GS: no significant association for cancer mortality (HR: 0.70; 95% CI: 0.48-1.02). CRF and GS are both independent predictors of mortality. Improving both CRF and muscle strength, as opposed to either of the two alone, may be the most effective behavioral strategy to reduce all-cause and cardiovascular mortality risk.
Keywords
Muscle, Skeletal, Humans, Cardiovascular Diseases, Hand Strength, Exercise, Cause of Death, Risk Factors, Prospective Studies, Physical Fitness, Aged, Middle Aged, Female, Male, Muscle Strength, United Kingdom, Cardiorespiratory Fitness
Sponsorship
MRC (MC_UU_12015/1)
MRC (MC_UU_12015/3)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
British Heart Foundation (FS/12/58/29709)
Embargo Lift Date
2100-01-01
Identifiers
External DOI: https://doi.org/10.1007/s10654-018-0384-x
This record's URL: https://www.repository.cam.ac.uk/handle/1810/275510
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