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dc.contributor.authorKim, Youngwonen
dc.contributor.authorWhite, Thomasen
dc.contributor.authorWijndaele, Katrienen
dc.contributor.authorWestgate, Kateen
dc.contributor.authorSharp, Stephenen
dc.contributor.authorHelge, Jørn Wen
dc.contributor.authorWareham, Nicholasen
dc.contributor.authorBrage, Sorenen
dc.date.accessioned2018-05-03T13:14:20Z
dc.date.available2018-05-03T13:14:20Z
dc.date.issued2018-10en
dc.identifier.issn0393-2990
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/275510
dc.description.abstractAbstract Little is known about the combined associations of cardiorespiratory fitness (CRF) and hand grip strength (GS) with mortality in general adult populations. The purpose of this study was to compare the relative risk of mortality for CRF, GS, and their combination. In UK Biobank, a prospective cohort of >0.5 million adults aged 40-69yrs, CRF was measured through submaximal bike tests; GS was measured using a hand-dynamometer. This analysis is based on data from 70,913 men and women (832 all-cause, 177 cardiovascular and 503 cancer deaths over 5.7-year follow-up) who provided valid CRF and GS data, and with no history of heart attack/stroke/cancer at baseline. Compared with the lowest CRF category, the hazard ratio (HR) for all-cause mortality was 0.76 (95% confidence interval [CI]: 0.64-0.89) and 0.65 (95% CI: 0.55-0.78) for the middle and highest CRF categories, respectively, after adjustment for confounders and GS. The highest GS category had an HR of 0.79 (95% CI: 0.66-0.95) for all-cause mortality compared with the lowest, after adjustment for confounders and CRF. Similar results were found for cardiovascular and cancer mortality. The HRs for the combination of highest CRF and GS were 0.53 (95% CI: 0.39-46 0.72) for all-cause mortality and 0.31 (95% CI: 0.14-0.67) for cardiovascular mortality, compared with the reference category of lowest CRF and GS: no significant association for cancer mortality (HR: 0.70; 95% CI: 0.48-1.02). CRF and GS are both independent predictors of mortality. Improving both CRF and muscle strength, as opposed to either of the two alone, may be the most effective behavioral strategy to reduce all-cause and cardiovascular mortality risk.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherSpringer Nature
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMuscle, Skeletalen
dc.subjectHumansen
dc.subjectCardiovascular Diseasesen
dc.subjectHand Strengthen
dc.subjectExerciseen
dc.subjectCause of Deathen
dc.subjectRisk Factorsen
dc.subjectProspective Studiesen
dc.subjectPhysical Fitnessen
dc.subjectAgeden
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectMuscle Strengthen
dc.subjectUnited Kingdomen
dc.subjectCardiorespiratory Fitnessen
dc.titleThe combination of cardiorespiratory fitness and muscle strength, and mortality risk.en
dc.typeArticle
prism.endingPage964
prism.issueIdentifier10en
prism.publicationDate2018en
prism.publicationNameEuropean journal of epidemiologyen
prism.startingPage953
prism.volume33en
dc.identifier.doi10.17863/CAM.22744
dcterms.dateAccepted2018-03-21en
rioxxterms.versionofrecord10.1007/s10654-018-0384-xen
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-10en
dc.contributor.orcidKim, Youngwon [0000-0002-7846-7191]
dc.contributor.orcidWhite, Thomas [0000-0001-8456-0803]
dc.contributor.orcidWijndaele, Katrien [0000-0003-2199-7981]
dc.contributor.orcidWestgate, Kate [0000-0002-0283-3562]
dc.contributor.orcidSharp, Stephen [0000-0003-2375-1440]
dc.contributor.orcidHelge, Jørn W [0000-0001-9724-5423]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidBrage, Soren [0000-0002-1265-7355]
dc.identifier.eissn1573-7284
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/1)
pubs.funder-project-idMRC (MC_UU_12015/3)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
pubs.funder-project-idBritish Heart Foundation (FS/12/58/29709)
cam.orpheus.successThu Jan 30 12:58:20 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International