Integrins promote axonal regeneration after injury of the nervous system.
Publication Date
2018-08Journal Title
Biol Rev Camb Philos Soc
ISSN
1464-7931
Publisher
Wiley
Volume
93
Issue
3
Pages
1339-1362
Language
eng
Type
Article
This Version
VoR
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Nieuwenhuis, B., Haenzi, B., Andrews, M. R., Verhaagen, J., & Fawcett, J. (2018). Integrins promote axonal regeneration after injury of the nervous system.. Biol Rev Camb Philos Soc, 93 (3), 1339-1362. https://doi.org/10.1111/brv.12398
Abstract
Integrins are cell surface receptors that form the link between extracellular matrix molecules of the cell environment and internal cell signalling and the cytoskeleton. They are involved in several processes, e.g. adhesion and migration during development and repair. This review focuses on the role of integrins in axonal regeneration. Integrins participate in spontaneous axonal regeneration in the peripheral nervous system through binding to various ligands that either inhibit or enhance their activation and signalling. Integrin biology is more complex in the central nervous system. Integrins receptors are transported into growing axons during development, but selective polarised transport of integrins limits the regenerative response in adult neurons. Manipulation of integrins and related molecules to control their activation state and localisation within axons is a promising route towards stimulating effective regeneration in the central nervous system.
Keywords
Axons, Animals, Wounds and Injuries, Integrins, Nerve Regeneration, Gene Expression Regulation
Sponsorship
International Foundation for Research in Paraplegia (IRP) (P172)
Medical Research Council (MR/R004544/1)
Medical Research Council (MR/R004463/1)
Medical Research Council (G1000864)
MRC (G1000864)
Spinal Research (ISRT) (NRB110)
Embargo Lift Date
2100-01-01
Identifiers
External DOI: https://doi.org/10.1111/brv.12398
This record's URL: https://www.repository.cam.ac.uk/handle/1810/275678
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