The integrated stress response in lung disease.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
van 't Wout, Emily FA
Hiemstra, Pieter S
Marciniak, Stefan J
Abstract
Lungs are repeatedly exposed to inhaled toxic insults, such as smoke, diesel exhaust, and microbes, which elicit cellular stress responses. The phosphorylation of eukaryotic translation initiation factor 2α by one of four stress-sensing kinases triggers a pathway called the integrated stress response that helps protect cellular reserves of nutrients and prevents the accumulation of toxic proteins. In this review, we discuss how activation of the integrated stress response has been shown to play an important role in pulmonary pathology, and how its study may help in the development of novel therapies for diverse conditions, from hypoxia to cancer.
Description
Keywords
Animals, Humans, Hypoxia, Lung, Lung Diseases, Neoplasms, Stress, Physiological
Journal Title
Am J Respir Cell Mol Biol
Conference Name
Journal ISSN
1044-1549
1535-4989
1535-4989
Volume Title
50
Publisher
American Thoracic Society
Publisher DOI
Sponsorship
Medical Research Council (G1002610)
Medical Research Council (G0601840)
Wellcome Trust (100140/Z/12/Z)
Medical Research Council (G0601840)
Wellcome Trust (100140/Z/12/Z)