Genetic susceptibility.
Accepted version
Peer-reviewed
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Abstract
Why only 20% of smokers develop clinically relevant chronic obstructive pulmonary disease (COPD) was a puzzle for many years. Now, epidemiologic studies point clearly toward a large heritable component. The combination of genome-wide association studies and candidate gene analysis is helping to identify those genetic variants responsible for an individual's susceptibility to developing COPD. In this review, the current data implicating specific loci and genes in the pathogenesis of COPD are examined.
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Keywords
COPD, Emphysema, GWAS, Genetics, SNP, Disease Susceptibility, Elastin, Extracellular Matrix, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Mutation, Peptide Hydrolases, Protease Inhibitors, Pulmonary Disease, Chronic Obstructive, Reactive Oxygen Species, alpha 1-Antitrypsin
Journal Title
Clin Chest Med
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Journal ISSN
0272-5231
1557-8216
1557-8216
Volume Title
35
Publisher
Elsevier
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Except where otherwised noted, this item's license is described as All rights reserved
Sponsorship
Medical Research Council (G1002610)
Medical Research Council (G0901786)
Medical Research Council (G0601840)
Wellcome Trust (100140/Z/12/Z)
Medical Research Council (G0901786)
Medical Research Council (G0601840)
Wellcome Trust (100140/Z/12/Z)