Genetic susceptibility.

Marciniak, Stefan; Lomas, David A

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Authors

Marciniak, Stefan

Lomas, David A

Publication Date

2014-03

Journal Title

Clin Chest Med

ISSN

0272-5231

Publisher

Elsevier BV

Volume

Issue

Pages

29-38

Language

eng

Type

Article

This Version

Physical Medium

Print-Electronic

Metadata

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Citation

Marciniak, S., & Lomas, D. A. (2014). Genetic susceptibility.. Clin Chest Med, 35 (1), 29-38. https://doi.org/10.1016/j.ccm.2013.10.008

Abstract

Why only 20% of smokers develop clinically relevant chronic obstructive pulmonary disease (COPD) was a puzzle for many years. Now, epidemiologic studies point clearly toward a large heritable component. The combination of genome-wide association studies and candidate gene analysis is helping to identify those genetic variants responsible for an individual's susceptibility to developing COPD. In this review, the current data implicating specific loci and genes in the pathogenesis of COPD are examined.

Keywords

Extracellular Matrix, Humans, Pulmonary Disease, Chronic Obstructive, Disease Susceptibility, Genetic Predisposition to Disease, Reactive Oxygen Species, Elastin, Peptide Hydrolases, alpha 1-Antitrypsin, Protease Inhibitors, Mutation, Genome-Wide Association Study

Sponsorship

Medical Research Council (G1002610)

Medical Research Council (G0901786)

Medical Research Council (G0601840)

Wellcome Trust (100140/Z/12/Z)

Identifiers

External DOI: https://doi.org/10.1016/j.ccm.2013.10.008

This record's URL: https://www.repository.cam.ac.uk/handle/1810/275915

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http://www.rioxx.net/licenses/all-rights-reserved

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