Repository logo
 

A network neuroscience approach to typical and atypical brain development

Accepted version
Peer-reviewed

No Thumbnail Available

Type

Article

Change log

Authors

Morgan, SE 
Bullmore, Edward T 

Abstract

Human brain networks based on neuroimaging data have already proven useful in characterising both normal and abnormal brain structure and function. However, many brain disorders are neurodevelopmental in origin, highlighting the need to go beyond characterizing brain organization in terms of static networks. Here we review the fast-growing literature shedding light on developmental changes in network phenotypes. We begin with an overview of recent large-scale efforts to map healthy brain development, and we describe the key role played by longitudinal data including repeated measurements over a long period of follow-up. We also discuss the subtle ways in which healthy brain network development can inform our understanding of disorders, including work bridging the gap between macroscopic neuroimaging results and the microscopic level. Finally, we turn to studies of three specific neurodevelopmental disorders which first manifest primarily in childhood and adolescence/early adulthood, namely psychotic disorders, attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). In each case we discuss recent progress in understanding the atypical features of brain network development associated with the disorder and we conclude the review with some suggestions for future directions.

Description

Keywords

Journal Title

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

Conference Name

Journal ISSN

Volume Title

Publisher

Elsevier

Publisher DOI

Publisher URL

Sponsorship
European Commission (603196)
Medical Research Council (MR/K020706/1)
MRC (1185)
MRC (unknown)
P.E.V. is supported by the MRC Grant MR/ K020706/1. S.E.M. is employed by the PSYSCAN project which is funded by the European Commission within its 7th Framework Programme under grant agreement number 603196. S.E.M. also holds a Junior Research Fellowship at Lucy Cavendish College, Cambridge funded by the Cambridge Philosophical Society. The Behavioural and Clinical Neuroscience Institute is supported by the Medical Research Council (United Kingdom) and the Wellcome Trust. S.R.W was supported by the Medical Research Council, UK (Unit Programme number U105292687).