Generation of the Maternal Low-Protein Rat Model for Studies of Metabolic Disorders.

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Authors
Ma, Dan
  Ozanne, Susan
Guest, Paul C
Publication Date
2018
Journal Title
Methods Mol Biol
ISSN
1064-3745
Publisher
Springer New York
Volume
1735
Pages
201-206
Language
eng
Type
Article
This Version
AM
Physical Medium
Print
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Citation
Ma, D., Ozanne, S., & Guest, P. C. (2018). Generation of the Maternal Low-Protein Rat Model for Studies of Metabolic Disorders.. Methods Mol Biol, 1735 201-206. https://doi.org/10.1007/978-1-4939-7614-0_10
Abstract
Poor nutrition during pregnancy leads to an increased risk of metabolic disorders and other diseases in the offspring. This can be modelled in animals through manipulation of the maternal diet. One such model is the maternal low-protein rat which gives rise to offspring characterized by insulin resistance. This chapter gives a detailed protocol for generation of the maternal low-protein rat, which has been used in the study of several disorders including diabetes and psychiatric disorders.
Keywords
Animals, Rats, Prenatal Exposure Delayed Effects, Metabolic Diseases, Protein Deficiency, Disease Models, Animal, Dietary Proteins, Maternal Exposure, Pregnancy, Female
Identifiers
External DOI: https://doi.org/10.1007/978-1-4939-7614-0_10
This record's URL: https://www.repository.cam.ac.uk/handle/1810/276414
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Licence:
http://www.rioxx.net/licenses/all-rights-reserved
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