Bioinspired Total Synthesis of Bussealin E.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Twigg, David G
Baldassarre, Leonardo
Frye, Elizabeth C
Galloway, Warren RJD
Spring, David R https://orcid.org/0000-0001-7355-2824
Abstract
The first total synthesis of bussealin E, a natural product with a unique cycloheptadibenzofuran scaffold, is reported. A strategy inspired by a proposed biosynthesis was employed whereby a diphenylpropane derivative underwent an oxidative phenolic coupling to forge the tetracyclic ring system. The synthesis of the diphenylpropane featured a key sp2-sp3 Hiyama coupling between a vinyldisiloxane and a benzylic bromide.
Description
Keywords
0305 Organic Chemistry
Journal Title
Org Lett
Conference Name
Journal ISSN
1523-7060
1523-7052
1523-7052
Volume Title
20
Publisher
American Chemical Society (ACS)
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/K039520/1)
European Research Council (279337)
European Research Council (279337)