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Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations.

Published version
Peer-reviewed

Type

Article

Change log

Authors

van Duijnhoven, Fränzel JB  ORCID logo  https://orcid.org/0000-0001-8367-2352
Jenab, Mazda 
Hveem, Kristian 
Siersema, Peter D 
Fedirko, Veronika 

Abstract

Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.

Description

Keywords

cancer epidemiology, nested case-control study, pancreatic cancer, vitamin D, 25-Hydroxyvitamin D 2, Aged, Calcifediol, Case-Control Studies, Europe, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Pancreatic Neoplasms, Prospective Studies, Risk Assessment, Seasons

Journal Title

Int J Cancer

Conference Name

Journal ISSN

0020-7136
1097-0215

Volume Title

142

Publisher

Wiley
Sponsorship
Medical Research Council (MC_UU_12015/1)
Medical Research Council (unknown)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Medical Research Council (G0800603)
Medical Research Council (G1000143)
Cancer Research Uk (None)
Cancer Research Uk (None)
Cancer Research Uk (None)
Medical Research Council (G0500300)
Medical Research Council (G0401527)
Cancer Research Uk (None)
Public Health Executive Agency (2006315)
Department of Health (via National Institute for Health Research (NIHR)) (unknown)
National Institute for Health Research (NIHR) (NF-SI-0512-10114)
Medical Research Council (MR/N003284/1)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
Medical Research Council (G0401527/1)