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dc.contributor.authorvan Duijnhoven, Fränzel JBen
dc.contributor.authorJenab, Mazdaen
dc.contributor.authorHveem, Kristianen
dc.contributor.authorSiersema, Peter Den
dc.contributor.authorFedirko, Veronikaen
dc.contributor.authorDuell, Eric Jen
dc.contributor.authorKampman, Ellenen
dc.contributor.authorHalfweeg, Anouken
dc.contributor.authorvan Kranen, Henk Jen
dc.contributor.authorvan den Ouweland, Jody MWen
dc.contributor.authorWeiderpass, Elisabeteen
dc.contributor.authorMurphy, Neilen
dc.contributor.authorLanghammer, Arnulfen
dc.contributor.authorNess-Jensen, Eivinden
dc.contributor.authorOlsen, Anjaen
dc.contributor.authorTjønneland, Anneen
dc.contributor.authorOvervad, Kimen
dc.contributor.authorCadeau, Claireen
dc.contributor.authorKvaskoff, Marinaen
dc.contributor.authorBoutron-Ruault, Marie-Christineen
dc.contributor.authorKatzke, Verena Aen
dc.contributor.authorKühn, Tilmanen
dc.contributor.authorBoeing, Heineren
dc.contributor.authorTrichopoulou, Antoniaen
dc.contributor.authorKotanidou, Anastasiaen
dc.contributor.authorKritikou, Mariaen
dc.contributor.authorPalli, Domenicoen
dc.contributor.authorAgnoli, Claudiaen
dc.contributor.authorTumino, Rosarioen
dc.contributor.authorPanico, Salvatoreen
dc.contributor.authorMatullo, Giuseppeen
dc.contributor.authorPeeters, Petraen
dc.contributor.authorBrustad, Magritten
dc.contributor.authorOlsen, Karina Standahlen
dc.contributor.authorLasheras, Cristinaen
dc.contributor.authorObón-Santacana, Mireiaen
dc.contributor.authorSánchez, María-Joséen
dc.contributor.authorDorronsoro, Mirenen
dc.contributor.authorChirlaque, Maria-Doloresen
dc.contributor.authorBarricarte, Aurelioen
dc.contributor.authorManjer, Jonasen
dc.contributor.authorAlmquist, Martinen
dc.contributor.authorRenström, Fridaen
dc.contributor.authorYe, Weiminen
dc.contributor.authorWareham, Nicholasen
dc.contributor.authorKhaw, Kay-Teeen
dc.contributor.authorBradbury, Kathryn Een
dc.contributor.authorFreisling, Heinzen
dc.contributor.authorAune, Dagfinnen
dc.contributor.authorNorat, Teresaen
dc.contributor.authorRiboli, Elioen
dc.contributor.authorBueno-de-Mesquita, HB Asen
dc.date.accessioned2018-06-18T12:39:06Z
dc.date.available2018-06-18T12:39:06Z
dc.date.issued2018-03en
dc.identifier.issn0020-7136
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/277164
dc.description.abstractEvidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2and 25(OH)D3combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherWiley-Blackwell
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHumansen
dc.subjectPancreatic Neoplasmsen
dc.subjectCalcifediolen
dc.subject25-Hydroxyvitamin D 2en
dc.subjectIncidenceen
dc.subjectRisk Assessmenten
dc.subjectCase-Control Studiesen
dc.subjectFollow-Up Studiesen
dc.subjectProspective Studiesen
dc.subjectSeasonsen
dc.subjectAgeden
dc.subjectMiddle Ageden
dc.subjectEuropeen
dc.subjectFemaleen
dc.subjectMaleen
dc.titleCirculating concentrations of vitamin D in relation to pancreatic cancer risk in European populations.en
dc.typeArticle
prism.endingPage1201
prism.issueIdentifier6en
prism.publicationDate2018en
prism.publicationNameInternational journal of canceren
prism.startingPage1189
prism.volume142en
dc.identifier.doi10.17863/CAM.24454
dcterms.dateAccepted2017-09-20en
rioxxterms.versionofrecord10.1002/ijc.31146en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-03en
dc.contributor.orcidvan Duijnhoven, Fränzel JB [0000-0001-8367-2352]
dc.contributor.orcidJenab, Mazda [0000-0002-0573-1852]
dc.contributor.orcidDuell, Eric J [0000-0001-5256-0163]
dc.contributor.orcidWeiderpass, Elisabete [0000-0003-2237-0128]
dc.contributor.orcidMurphy, Neil [0000-0003-3347-8249]
dc.contributor.orcidTjønneland, Anne [0000-0003-4385-2097]
dc.contributor.orcidOvervad, Kim [0000-0001-6429-7921]
dc.contributor.orcidKvaskoff, Marina [0000-0002-4557-3772]
dc.contributor.orcidKühn, Tilman [0000-0001-7702-317X]
dc.contributor.orcidPalli, Domenico [0000-0002-5558-2437]
dc.contributor.orcidAgnoli, Claudia [0000-0003-4472-1179]
dc.contributor.orcidTumino, Rosario [0000-0003-2666-414X]
dc.contributor.orcidMatullo, Giuseppe [0000-0003-0674-7757]
dc.contributor.orcidObón-Santacana, Mireia [0000-0003-4646-3513]
dc.contributor.orcidSánchez, María-José [0000-0003-4817-0757]
dc.contributor.orcidYe, Weimin [0000-0002-6859-4648]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidKhaw, Kay-Tee [0000-0002-8802-2903]
dc.contributor.orcidBradbury, Kathryn E [0000-0003-3345-7333]
dc.contributor.orcidFreisling, Heinz [0000-0001-8648-4998]
dc.contributor.orcidAune, Dagfinn [0000-0002-4533-1722]
dc.contributor.orcidRiboli, Elio [0000-0001-6795-6080]
dc.identifier.eissn1097-0215
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (unknown)
pubs.funder-project-idNational Institute for Health Research (NIHR) (NF-SI-0512-10114)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/N003284/1)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
pubs.funder-project-idPublic Health Executive Agency (2006315)
pubs.funder-project-idCancer Research UK (A2883)
pubs.funder-project-idMRC (G0401527)
pubs.funder-project-idMRC (G0500300)
pubs.funder-project-idCancer Research UK (A7744)
pubs.funder-project-idCancer Research UK (14136)
pubs.funder-project-idCancer Research UK (A8257)
pubs.funder-project-idMRC (G1000143)
pubs.funder-project-idMRC (G0800603)
pubs.funder-project-idMRC (MC_UU_12015/1)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
pubs.funder-project-idMedical Research Council (unknown)


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