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11C-metomidate PET-CT scanning can identify aldosterone-producing adenomas after unsuccessful lateralisation with CT/MRI and adrenal venous sampling.

Accepted version
Peer-reviewed

Type

Article

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Authors

Ouyang, J 
Hardy, R 
Brown, M 
Helliwell, T 

Abstract

Primary hyperaldosteronism, characterised by hypertension and hypokalaemia, is a syndrome caused by aldosterone excess most commonly from either a unilateral aldosterone-producing adenoma or bilateral adrenal hyperplasia. Subtype classification can be challenging with cross-sectional imaging and even with interventional radiological techniques such as adrenal venous sampling. Imaging with 11C-metomidate positron emission tomography-computed tomography (PET-CT) is an emerging tool that facilitates functional characterisation and potentially successful surgical intervention of aldosterone-producing adenomas. This technique has highlighted that, although unilateral adenomas and bilateral hyperplasia represent opposite ends of the disease spectrum, a relatively common intermediate phenotype exists of unilateral/bilateral multinodular disease.

Description

Keywords

Adenoma, Adrenal Gland Neoplasms, Aldosterone, Etomidate, Humans, Positron Emission Tomography Computed Tomography

Journal Title

J Hum Hypertens

Conference Name

Journal ISSN

0950-9240
1476-5527

Volume Title

31

Publisher

Springer Science and Business Media LLC
Sponsorship
Medical Research Council (MR/M009041/1)
Medical Research Council (MR/M024873/1)